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Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study.

Abstract

BACKGROUND

Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI.

OBJECTIVES

The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population-based study.

PATIENTS AND METHODS

Traditional cardiovascular risk factors and family history of MI were registered in 21,330 subjects, aged 25-96 years, enrolled in the Tromsø study in 1994-95. First-lifetime VTE events during follow-up were registered up to 1 September 2007.

RESULTS

There were 327 VTE events (1.40 per 1000 person-years), 138 (42%) unprovoked, during a mean of 10.9 years of follow-up. In age- and gender-adjusted analysis, age [hazard ratio (HR) per decade, 1.97; 95% confidence interval (CI), 1.82-2.12], gender (men vs. women; HR, 1.25; 95% CI, 1.01-1.55), body mass index (BMI; HR per 3 kg m(-2), 1.21; 95% CI, 1.13-1.31), and family history of MI (HR, 1.31; 95% CI, 1.04-1.65) were significantly associated with VTE. Family history of MI remained a significant risk factor for total VTE (HR, 1.27; 95% CI, 1.01-1.60) and unprovoked VTE (HR, 1.46; 95% CI, 1.03-2.07) in multivariable analysis. Blood pressure, total cholesterol, HDL-cholesterol, triglycerides, and smoking were not independently associated with total VTE.

CONCLUSIONS

Family history of MI is a risk factor for both MI and VTE, and provides further evidence of a link between venous and arterial thrombosis.

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  • Authors+Show Affiliations

    ,

    Center for Atherothrombotic Research in Tromsø, Department of Medicine, University of Tromsø, Tromsø, Norway. sigrid.braekkan@fagmed.uit.no

    , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Body Mass Index
    Family Health
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Myocardial Infarction
    Pregnancy
    Prospective Studies
    Risk Factors
    Sex Factors
    Venous Thromboembolism

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18665924

    Citation

    Braekkan, S K., et al. "Family History of Myocardial Infarction Is an Independent Risk Factor for Venous Thromboembolism: the Tromsø Study." Journal of Thrombosis and Haemostasis : JTH, vol. 6, no. 11, 2008, pp. 1851-7.
    Braekkan SK, Mathiesen EB, Njølstad I, et al. Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study. J Thromb Haemost. 2008;6(11):1851-7.
    Braekkan, S. K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., Størmer, J., & Hansen, J. B. (2008). Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study. Journal of Thrombosis and Haemostasis : JTH, 6(11), pp. 1851-7. doi:10.1111/j.1538-7836.2008.03102.x.
    Braekkan SK, et al. Family History of Myocardial Infarction Is an Independent Risk Factor for Venous Thromboembolism: the Tromsø Study. J Thromb Haemost. 2008;6(11):1851-7. PubMed PMID: 18665924.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study. AU - Braekkan,S K, AU - Mathiesen,E B, AU - Njølstad,I, AU - Wilsgaard,T, AU - Størmer,J, AU - Hansen,J B, Y1 - 2008/07/26/ PY - 2008/7/31/pubmed PY - 2009/1/1/medline PY - 2008/7/31/entrez SP - 1851 EP - 7 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 6 IS - 11 N2 - BACKGROUND: Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI. OBJECTIVES: The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population-based study. PATIENTS AND METHODS: Traditional cardiovascular risk factors and family history of MI were registered in 21,330 subjects, aged 25-96 years, enrolled in the Tromsø study in 1994-95. First-lifetime VTE events during follow-up were registered up to 1 September 2007. RESULTS: There were 327 VTE events (1.40 per 1000 person-years), 138 (42%) unprovoked, during a mean of 10.9 years of follow-up. In age- and gender-adjusted analysis, age [hazard ratio (HR) per decade, 1.97; 95% confidence interval (CI), 1.82-2.12], gender (men vs. women; HR, 1.25; 95% CI, 1.01-1.55), body mass index (BMI; HR per 3 kg m(-2), 1.21; 95% CI, 1.13-1.31), and family history of MI (HR, 1.31; 95% CI, 1.04-1.65) were significantly associated with VTE. Family history of MI remained a significant risk factor for total VTE (HR, 1.27; 95% CI, 1.01-1.60) and unprovoked VTE (HR, 1.46; 95% CI, 1.03-2.07) in multivariable analysis. Blood pressure, total cholesterol, HDL-cholesterol, triglycerides, and smoking were not independently associated with total VTE. CONCLUSIONS: Family history of MI is a risk factor for both MI and VTE, and provides further evidence of a link between venous and arterial thrombosis. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/18665924/Family_history_of_myocardial_infarction_is_an_independent_risk_factor_for_venous_thromboembolism:_the_Tromsø_study_ L2 - https://doi.org/10.1111/j.1538-7836.2008.03102.x DB - PRIME DP - Unbound Medicine ER -