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Placental transfer of DDT in mother-infant pairs from Northern Thailand.
J Environ Sci Health B. 2008 Aug; 43(6):484-9.JE

Abstract

The present study objective was to investigate ratios and correlation coefficients between dichlorodiphenyltrichloroethane (DDT) compounds in cord and maternal sera of mother-infant pairs from northern Thailand. The study site was located in Chiang Dao District of Chiang Mai Province which was an agricultural and former malaria endemic area. DDT compounds were analyzed in 88 cord and maternal serum samples using gas chromatography-electron capture detection (GC-ECD). p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) was the major component and detected in every cord and maternal serum samples with geometric means of 1,255 and 1,793 n g(-1) lipids, respectively. p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) was detected at 89.8 and 100% of cord and maternal serum samples, respectively. The second and third highest levels detected were p,p'-DDD (1,1-dichloro-2,2-bis(p-chlorophenyl)ethane) and p,p'-DDT, respectively. The ratios between cord and maternal sera for p,p'-DDE, p,p'-DDT, and p,p'-DDD that were less than 1 had high correlation coefficients (ratio = 0.70, r = 0.82 for p,p'-DDE, ratio = 0.62, r = 0.66 for p,p'-DDT, and ratio = 0.79, r = 0.78 for p,p'-DDD). The high correlation coefficients indicate that cord serum levels of DDT compounds could be accurately estimated from maternal serum levels. It can be concluded that cord serum levels of p,p'-DDE, p,p'-DDT, and p,p'-DDD were approximately 70%, 62%, and 79% of maternal serum levels, respectively. Furthermore, our findings can be applied in public health to monitor and evaluate risk among infants from high DDT exposure area.

Authors+Show Affiliations

Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18665984

Citation

Sapbamrer, Ratana, et al. "Placental Transfer of DDT in Mother-infant Pairs From Northern Thailand." Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, vol. 43, no. 6, 2008, pp. 484-9.
Sapbamrer R, Prapamontol T, Prakobvitayakit O, et al. Placental transfer of DDT in mother-infant pairs from Northern Thailand. J Environ Sci Health B. 2008;43(6):484-9.
Sapbamrer, R., Prapamontol, T., Prakobvitayakit, O., Vaneesorn, Y., Mangklabruks, A., & Hock, B. (2008). Placental transfer of DDT in mother-infant pairs from Northern Thailand. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, 43(6), 484-9. https://doi.org/10.1080/03601230802174615
Sapbamrer R, et al. Placental Transfer of DDT in Mother-infant Pairs From Northern Thailand. J Environ Sci Health B. 2008;43(6):484-9. PubMed PMID: 18665984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental transfer of DDT in mother-infant pairs from Northern Thailand. AU - Sapbamrer,Ratana, AU - Prapamontol,Tippawan, AU - Prakobvitayakit,Ookaew, AU - Vaneesorn,Yuthsak, AU - Mangklabruks,Ampica, AU - Hock,Bertold, PY - 2008/7/31/pubmed PY - 2008/10/16/medline PY - 2008/7/31/entrez SP - 484 EP - 9 JF - Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes JO - J Environ Sci Health B VL - 43 IS - 6 N2 - The present study objective was to investigate ratios and correlation coefficients between dichlorodiphenyltrichloroethane (DDT) compounds in cord and maternal sera of mother-infant pairs from northern Thailand. The study site was located in Chiang Dao District of Chiang Mai Province which was an agricultural and former malaria endemic area. DDT compounds were analyzed in 88 cord and maternal serum samples using gas chromatography-electron capture detection (GC-ECD). p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) was the major component and detected in every cord and maternal serum samples with geometric means of 1,255 and 1,793 n g(-1) lipids, respectively. p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) was detected at 89.8 and 100% of cord and maternal serum samples, respectively. The second and third highest levels detected were p,p'-DDD (1,1-dichloro-2,2-bis(p-chlorophenyl)ethane) and p,p'-DDT, respectively. The ratios between cord and maternal sera for p,p'-DDE, p,p'-DDT, and p,p'-DDD that were less than 1 had high correlation coefficients (ratio = 0.70, r = 0.82 for p,p'-DDE, ratio = 0.62, r = 0.66 for p,p'-DDT, and ratio = 0.79, r = 0.78 for p,p'-DDD). The high correlation coefficients indicate that cord serum levels of DDT compounds could be accurately estimated from maternal serum levels. It can be concluded that cord serum levels of p,p'-DDE, p,p'-DDT, and p,p'-DDD were approximately 70%, 62%, and 79% of maternal serum levels, respectively. Furthermore, our findings can be applied in public health to monitor and evaluate risk among infants from high DDT exposure area. SN - 1532-4109 UR - https://www.unboundmedicine.com/medline/citation/18665984/Placental_transfer_of_DDT_in_mother_infant_pairs_from_Northern_Thailand_ L2 - https://www.tandfonline.com/doi/full/10.1080/03601230802174615 DB - PRIME DP - Unbound Medicine ER -