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Analysis of the volatile chemical markers of explosives using novel solid phase microextraction coupled to ion mobility spectrometry.
J Sep Sci. 2008 Aug; 31(15):2891-8.JS

Abstract

Ion mobility spectrometry (IMS) is routinely used in screening checkpoints for the detection of explosives and illicit drugs but it mainly relies on the capture of particles on a swab surface for the detection. Solid phase microextraction (SPME) has been coupled to IMS for the preconcentration of explosives and their volatile chemical markers and, although it has improved the LODs over a standalone IMS, it is limited to sampling in small vessels by the fiber geometry. Novel planar geometry SPME devices coated with PDMS and sol-gel PDMS that do not require an additional interface to IMS are now reported for the first time. The explosive, 2,4,6-trinitrotoluene (TNT), is sampled with the planar SPME reaching extraction equilibrium faster than with fiber SPME, concentrating detectable levels of TNT in a matter of minutes. The surface area, capacity, extraction efficiency, and LODs are also improved over fiber SPME allowing for sampling in larger volumes. The volatile chemical markers, 2,4-dinitrotoluene, cyclohexanone, and the taggant 4-nitrotoluene have also been successfully extracted by planar SPME and detected by IMS at mass loadings below 1 ng of extracted analyte on the planar device for TNT, for example.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, Miami 33199, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18666175

Citation

Guerra, Patricia, et al. "Analysis of the Volatile Chemical Markers of Explosives Using Novel Solid Phase Microextraction Coupled to Ion Mobility Spectrometry." Journal of Separation Science, vol. 31, no. 15, 2008, pp. 2891-8.
Guerra P, Lai H, Almirall JR. Analysis of the volatile chemical markers of explosives using novel solid phase microextraction coupled to ion mobility spectrometry. J Sep Sci. 2008;31(15):2891-8.
Guerra, P., Lai, H., & Almirall, J. R. (2008). Analysis of the volatile chemical markers of explosives using novel solid phase microextraction coupled to ion mobility spectrometry. Journal of Separation Science, 31(15), 2891-8. https://doi.org/10.1002/jssc.200800171
Guerra P, Lai H, Almirall JR. Analysis of the Volatile Chemical Markers of Explosives Using Novel Solid Phase Microextraction Coupled to Ion Mobility Spectrometry. J Sep Sci. 2008;31(15):2891-8. PubMed PMID: 18666175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the volatile chemical markers of explosives using novel solid phase microextraction coupled to ion mobility spectrometry. AU - Guerra,Patricia, AU - Lai,Hanh, AU - Almirall,José R, PY - 2008/7/31/pubmed PY - 2008/11/8/medline PY - 2008/7/31/entrez SP - 2891 EP - 8 JF - Journal of separation science JO - J Sep Sci VL - 31 IS - 15 N2 - Ion mobility spectrometry (IMS) is routinely used in screening checkpoints for the detection of explosives and illicit drugs but it mainly relies on the capture of particles on a swab surface for the detection. Solid phase microextraction (SPME) has been coupled to IMS for the preconcentration of explosives and their volatile chemical markers and, although it has improved the LODs over a standalone IMS, it is limited to sampling in small vessels by the fiber geometry. Novel planar geometry SPME devices coated with PDMS and sol-gel PDMS that do not require an additional interface to IMS are now reported for the first time. The explosive, 2,4,6-trinitrotoluene (TNT), is sampled with the planar SPME reaching extraction equilibrium faster than with fiber SPME, concentrating detectable levels of TNT in a matter of minutes. The surface area, capacity, extraction efficiency, and LODs are also improved over fiber SPME allowing for sampling in larger volumes. The volatile chemical markers, 2,4-dinitrotoluene, cyclohexanone, and the taggant 4-nitrotoluene have also been successfully extracted by planar SPME and detected by IMS at mass loadings below 1 ng of extracted analyte on the planar device for TNT, for example. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/18666175/Analysis_of_the_volatile_chemical_markers_of_explosives_using_novel_solid_phase_microextraction_coupled_to_ion_mobility_spectrometry_ L2 - https://doi.org/10.1002/jssc.200800171 DB - PRIME DP - Unbound Medicine ER -