Ji, C M., et al. "Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil." Journal of Biomaterials Applications, vol. 23, no. 4, 2009, pp. 311-29.
Ji CM, Xu HN, Wu W. Guar gum as potential film coating material for colon-specific delivery of fluorouracil. J Biomater Appl. 2009;23(4):311-29.
Ji, C. M., Xu, H. N., & Wu, W. (2009). Guar gum as potential film coating material for colon-specific delivery of fluorouracil. Journal of Biomaterials Applications, 23(4), 311-29. https://doi.org/10.1177/0885328208089617
Ji CM, Xu HN, Wu W. Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil. J Biomater Appl. 2009;23(4):311-29. PubMed PMID: 18667456.
TY - JOUR
T1 - Guar gum as potential film coating material for colon-specific delivery of fluorouracil.
AU - Ji,C M,
AU - Xu,H N,
AU - Wu,W,
Y1 - 2008/07/30/
PY - 2008/8/1/pubmed
PY - 2009/2/5/medline
PY - 2008/8/1/entrez
SP - 311
EP - 29
JF - Journal of biomaterials applications
JO - J Biomater Appl
VL - 23
IS - 4
N2 - The potential of guar gum as a film coating material for colon-specific delivery of 5-fluorouracil is evaluated in this study. The guar gum-based multi-unit pellet system is prepared by coating guar gum and pH-sensitive polymer Eudragit FS30D sequentially around drug-loaded non-pareil cores in a fluid-bed coater. The outer Eudragit FS coating protects the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the pellets until it is degraded by microbial enzymes at the proximal colon. In vitro results indicate that guar gum is a feasible coating material to achieve timed and enzyme-triggered fluorouracil release. Pharmacokinetic study in beagle dogs shows delayed absorption of about 5 h and limited absorption fraction as a result of guar gum and Eudragit FS coating.
SN - 0885-3282
UR - https://www.unboundmedicine.com/medline/citation/18667456/Guar_gum_as_potential_film_coating_material_for_colon_specific_delivery_of_fluorouracil_
L2 - https://journals.sagepub.com/doi/10.1177/0885328208089617?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed
DB - PRIME
DP - Unbound Medicine