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Guar gum as potential film coating material for colon-specific delivery of fluorouracil.
J Biomater Appl. 2009 Jan; 23(4):311-29.JB

Abstract

The potential of guar gum as a film coating material for colon-specific delivery of 5-fluorouracil is evaluated in this study. The guar gum-based multi-unit pellet system is prepared by coating guar gum and pH-sensitive polymer Eudragit FS30D sequentially around drug-loaded non-pareil cores in a fluid-bed coater. The outer Eudragit FS coating protects the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the pellets until it is degraded by microbial enzymes at the proximal colon. In vitro results indicate that guar gum is a feasible coating material to achieve timed and enzyme-triggered fluorouracil release. Pharmacokinetic study in beagle dogs shows delayed absorption of about 5 h and limited absorption fraction as a result of guar gum and Eudragit FS coating.

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Publisher Full Text

Authors+Show Affiliations

Ji CM
School of Pharmacy, Fudan University, Shanghai 200032, China.
Xu HN
No affiliation info available
Wu W
No affiliation info available

MeSH

AnimalsCecumCoated Materials, BiocompatibleColonDogsDrug Delivery SystemsFluorouracilGalactansHydrogen-Ion ConcentrationIn Vitro TechniquesIntestinal AbsorptionKineticsMannansMannosidasesMaterials TestingMicroscopy, Electron, ScanningPlant GumsPolymethacrylic AcidsTablets, Enteric-Coated

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18667456

Citation

Ji, C M., et al. "Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil." Journal of Biomaterials Applications, vol. 23, no. 4, 2009, pp. 311-29.
Ji CM, Xu HN, Wu W. Guar gum as potential film coating material for colon-specific delivery of fluorouracil. J Biomater Appl. 2009;23(4):311-29.
Ji, C. M., Xu, H. N., & Wu, W. (2009). Guar gum as potential film coating material for colon-specific delivery of fluorouracil. Journal of Biomaterials Applications, 23(4), 311-29. https://doi.org/10.1177/0885328208089617
Ji CM, Xu HN, Wu W. Guar Gum as Potential Film Coating Material for Colon-specific Delivery of Fluorouracil. J Biomater Appl. 2009;23(4):311-29. PubMed PMID: 18667456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guar gum as potential film coating material for colon-specific delivery of fluorouracil. AU - Ji,C M, AU - Xu,H N, AU - Wu,W, Y1 - 2008/07/30/ PY - 2008/8/1/pubmed PY - 2009/2/5/medline PY - 2008/8/1/entrez SP - 311 EP - 29 JF - Journal of biomaterials applications JO - J Biomater Appl VL - 23 IS - 4 N2 - The potential of guar gum as a film coating material for colon-specific delivery of 5-fluorouracil is evaluated in this study. The guar gum-based multi-unit pellet system is prepared by coating guar gum and pH-sensitive polymer Eudragit FS30D sequentially around drug-loaded non-pareil cores in a fluid-bed coater. The outer Eudragit FS coating protects the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the pellets until it is degraded by microbial enzymes at the proximal colon. In vitro results indicate that guar gum is a feasible coating material to achieve timed and enzyme-triggered fluorouracil release. Pharmacokinetic study in beagle dogs shows delayed absorption of about 5 h and limited absorption fraction as a result of guar gum and Eudragit FS coating. SN - 0885-3282 UR - https://www.unboundmedicine.com/medline/citation/18667456/Guar_gum_as_potential_film_coating_material_for_colon_specific_delivery_of_fluorouracil_ L2 - https://journals.sagepub.com/doi/10.1177/0885328208089617?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -