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High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome.
Med Sci Monit. 2008 Aug; 14(8):CR411-5.MS

Abstract

BACKGROUND

High-sensitivity C-reactive protein is an important biomarker of systemic inflammation. We studied the contribution to cardiovascular risk of increased high-sensitivity C-reactive protein in patients with type 2 diabetes with or without concomitant metabolic syndrome.

MATERIAL/METHODS

The series included 381 patients (199 men, 182 women; median age, 66 years; age range, 50-80 years) with a mean duration of type 2 diabetes of 9+/-8 years. Standard physical examinations and laboratory investigations were administered to all patients. Modified National Cholesterol Education Program III criteria for defining the metabolic syndrome were used. High-sensitivity C-reactive protein was estimated by immunoturbidimetry and other laboratory tests using standard methods.

RESULTS

High-sensitivity C-reactive protein correlated (Spearman's correlation) significantly positively with body mass index and waist size, fasting plasma triglyceride levels, apolipoprotein-B, gamma glutamyl transferase, homeostasis model assessment of insulin resistance, and fibrinogen, and negatively with high-density lipoprotein cholesterol. However, only waist, fibrinogen, apolipoprotein-B, plasma glucose, and gamma glutamyl transferase levels appeared to be associated with high-sensitivity C-reactive protein on multiple logistic regression model analyses. In those diabetic patients with concomitant metabolic syndrome, the hypertriglyceridemic waist appeared to be a major factor for an increased high-sensitivity C-reactive protein concentration.

CONCLUSIONS

The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age.

Authors+Show Affiliations

Center of Preventive Cardiology, 2nd Medical Department, Charles University in Prague - Medical Faculty in Pilsen, Pilsen, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18667998

Citation

Rosolova, Hana, et al. "High-sensitivity C-reactive Protein and the Hypertriglyceridemic Waist in Patients With Type 2 Diabetes and Metabolic Syndrome." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 14, no. 8, 2008, pp. CR411-5.
Rosolova H, Petrlova B, Simon J, et al. High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome. Med Sci Monit. 2008;14(8):CR411-5.
Rosolova, H., Petrlova, B., Simon, J., Sifalda, P., & Sipova, I. (2008). High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 14(8), CR411-5.
Rosolova H, et al. High-sensitivity C-reactive Protein and the Hypertriglyceridemic Waist in Patients With Type 2 Diabetes and Metabolic Syndrome. Med Sci Monit. 2008;14(8):CR411-5. PubMed PMID: 18667998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome. AU - Rosolova,Hana, AU - Petrlova,Barbora, AU - Simon,Jaroslav, AU - Sifalda,Pavel, AU - Sipova,Iva, PY - 2008/8/1/pubmed PY - 2008/10/28/medline PY - 2008/8/1/entrez SP - CR411 EP - 5 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 14 IS - 8 N2 - BACKGROUND: High-sensitivity C-reactive protein is an important biomarker of systemic inflammation. We studied the contribution to cardiovascular risk of increased high-sensitivity C-reactive protein in patients with type 2 diabetes with or without concomitant metabolic syndrome. MATERIAL/METHODS: The series included 381 patients (199 men, 182 women; median age, 66 years; age range, 50-80 years) with a mean duration of type 2 diabetes of 9+/-8 years. Standard physical examinations and laboratory investigations were administered to all patients. Modified National Cholesterol Education Program III criteria for defining the metabolic syndrome were used. High-sensitivity C-reactive protein was estimated by immunoturbidimetry and other laboratory tests using standard methods. RESULTS: High-sensitivity C-reactive protein correlated (Spearman's correlation) significantly positively with body mass index and waist size, fasting plasma triglyceride levels, apolipoprotein-B, gamma glutamyl transferase, homeostasis model assessment of insulin resistance, and fibrinogen, and negatively with high-density lipoprotein cholesterol. However, only waist, fibrinogen, apolipoprotein-B, plasma glucose, and gamma glutamyl transferase levels appeared to be associated with high-sensitivity C-reactive protein on multiple logistic regression model analyses. In those diabetic patients with concomitant metabolic syndrome, the hypertriglyceridemic waist appeared to be a major factor for an increased high-sensitivity C-reactive protein concentration. CONCLUSIONS: The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/18667998/High_sensitivity_C_reactive_protein_and_the_hypertriglyceridemic_waist_in_patients_with_type_2_diabetes_and_metabolic_syndrome_ L2 - https://www.medscimonit.com/download/index/idArt/865790 DB - PRIME DP - Unbound Medicine ER -