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Deep brain stimulation effect on freezing of gait.
Mov Disord. 2008; 23 Suppl 2:S489-94.MD

Abstract

The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa-responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa-resistant FOG. In the few cases of levodopa-induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off- and on-levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients.

Authors+Show Affiliations

INSERM, U836, Grenoble Institute of Neuroscience, Grenoble, France. Murielle.Ferraye@e.ujf-grenoble.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18668617

Citation

Ferraye, Murielle U., et al. "Deep Brain Stimulation Effect On Freezing of Gait." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23 Suppl 2, 2008, pp. S489-94.
Ferraye MU, Deb슩 B, Pollak P. Deep brain stimulation effect on freezing of gait. Mov Disord. 2008;23 Suppl 2:S489-94.
Ferraye, M. U., Deb슩, B., & Pollak, P. (2008). Deep brain stimulation effect on freezing of gait. Movement Disorders : Official Journal of the Movement Disorder Society, 23 Suppl 2, S489-94. https://doi.org/10.1002/mds.21975
Ferraye MU, Deb슩 B, Pollak P. Deep Brain Stimulation Effect On Freezing of Gait. Mov Disord. 2008;23 Suppl 2:S489-94. PubMed PMID: 18668617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep brain stimulation effect on freezing of gait. AU - Ferraye,Murielle U, AU - Deb슩,Bettina, AU - Pollak,Pierre, PY - 2008/8/1/pubmed PY - 2008/12/23/medline PY - 2008/8/1/entrez SP - S489 EP - 94 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 Suppl 2 N2 - The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa-responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa-resistant FOG. In the few cases of levodopa-induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off- and on-levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18668617/Deep_brain_stimulation_effect_on_freezing_of_gait_ L2 - https://doi.org/10.1002/mds.21975 DB - PRIME DP - Unbound Medicine ER -