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Theta burst stimulation induces after-effects on contralateral primary motor cortex excitability in humans.
J Physiol. 2008 Sep 15; 586(18):4489-500.JP

Abstract

Interhemispheric interactions between the primary motor cortices (M1) have been described with a variety of TMS methods. Here we give a detailed description of the interhemispheric interactions of a period of theta burst simulation (TBS), a rapid method of producing long lasting after-effects on the excitability of the stimulated M1. A total of 18 right handed healthy subjects participated. In most experiments, continuous and intermittent TBS (cTBS and iTBS) were delivered over the right M1 using a coil orientated to induce antero-posterior followed by postero-anterior (AP-PA) currents in the brain. The intensity of stimulation was 80% of active motor threshold (AMT), and a total of 600 pulses were applied. The effects on the amplitude of motor evoked potentials (MEPs), short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were evaluated in the left and right M1 before and at three different times after TBS. We also tested long-interval intracortical inhibition (LICI) in right M1 and interhemispheric inhibition (IHI) from right to left M1. Finally, to explore the effect of different polarities of cTBS over dominant and non-dominant hemisphere we delivered AP-PA and postero-anterior followed by antero-posterior (PA-AP) cTBS over either right or left M1 and tested MEPs in both hemispheres. In the stimulated hemisphere, cTBS reduced MEPs and SICI whereas iTBS increased MEPs and SICI. In the non-stimulated hemisphere cTBS increased MEPs and reduced SICI, while iTBS reduced MEPs and increased SICI. There were no effects on ICF, LICI or IHI. Although both AP-PA cTBS and PA-AP cTBS reduced MEPs in the stimulated M1, the former increased MEPs from non-stimulated M1 whereas the latter did not. There was no difference in the effect of cTBS on the dominant or non-dominant hemisphere.

Authors+Show Affiliations

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3BG, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18669534

Citation

Suppa, A, et al. "Theta Burst Stimulation Induces After-effects On Contralateral Primary Motor Cortex Excitability in Humans." The Journal of Physiology, vol. 586, no. 18, 2008, pp. 4489-500.
Suppa A, Ortu E, Zafar N, et al. Theta burst stimulation induces after-effects on contralateral primary motor cortex excitability in humans. J Physiol (Lond). 2008;586(18):4489-500.
Suppa, A., Ortu, E., Zafar, N., Deriu, F., Paulus, W., Berardelli, A., & Rothwell, J. C. (2008). Theta burst stimulation induces after-effects on contralateral primary motor cortex excitability in humans. The Journal of Physiology, 586(18), 4489-500. https://doi.org/10.1113/jphysiol.2008.156596
Suppa A, et al. Theta Burst Stimulation Induces After-effects On Contralateral Primary Motor Cortex Excitability in Humans. J Physiol (Lond). 2008 Sep 15;586(18):4489-500. PubMed PMID: 18669534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Theta burst stimulation induces after-effects on contralateral primary motor cortex excitability in humans. AU - Suppa,A, AU - Ortu,E, AU - Zafar,N, AU - Deriu,F, AU - Paulus,W, AU - Berardelli,A, AU - Rothwell,J C, Y1 - 2008/07/31/ PY - 2008/8/2/pubmed PY - 2009/1/16/medline PY - 2008/8/2/entrez SP - 4489 EP - 500 JF - The Journal of physiology JO - J. Physiol. (Lond.) VL - 586 IS - 18 N2 - Interhemispheric interactions between the primary motor cortices (M1) have been described with a variety of TMS methods. Here we give a detailed description of the interhemispheric interactions of a period of theta burst simulation (TBS), a rapid method of producing long lasting after-effects on the excitability of the stimulated M1. A total of 18 right handed healthy subjects participated. In most experiments, continuous and intermittent TBS (cTBS and iTBS) were delivered over the right M1 using a coil orientated to induce antero-posterior followed by postero-anterior (AP-PA) currents in the brain. The intensity of stimulation was 80% of active motor threshold (AMT), and a total of 600 pulses were applied. The effects on the amplitude of motor evoked potentials (MEPs), short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were evaluated in the left and right M1 before and at three different times after TBS. We also tested long-interval intracortical inhibition (LICI) in right M1 and interhemispheric inhibition (IHI) from right to left M1. Finally, to explore the effect of different polarities of cTBS over dominant and non-dominant hemisphere we delivered AP-PA and postero-anterior followed by antero-posterior (PA-AP) cTBS over either right or left M1 and tested MEPs in both hemispheres. In the stimulated hemisphere, cTBS reduced MEPs and SICI whereas iTBS increased MEPs and SICI. In the non-stimulated hemisphere cTBS increased MEPs and reduced SICI, while iTBS reduced MEPs and increased SICI. There were no effects on ICF, LICI or IHI. Although both AP-PA cTBS and PA-AP cTBS reduced MEPs in the stimulated M1, the former increased MEPs from non-stimulated M1 whereas the latter did not. There was no difference in the effect of cTBS on the dominant or non-dominant hemisphere. SN - 1469-7793 UR - https://www.unboundmedicine.com/medline/citation/18669534/Theta_burst_stimulation_induces_after_effects_on_contralateral_primary_motor_cortex_excitability_in_humans_ L2 - https://doi.org/10.1113/jphysiol.2008.156596 DB - PRIME DP - Unbound Medicine ER -