Tags

Type your tag names separated by a space and hit enter

Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
Fitoterapia. 2008 Dec; 79(7-8):557-61.F

Abstract

The aqueous extract of Ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. The results of the present study showed that intraperitoneal administration of the F. deltoidea leaves aqueous extract at the dose of 1, 50 and 100 mg/kg, 30 min prior to pain induction produced significant dose-dependent antinociceptive effect in all the models used, which indicating the presence of both central and peripherally mediated activities. Furthermore, the antinociceptive effect of the extract in the formalin and hot plate test was reversed by the non-selective opioid receptor antagonist naloxone suggesting that the endogenous opioid system is involved in its analgesic mechanism of action. Thus, the present results demonstrated that F. deltoidea leaves aqueous extract contains pharmacologically active constituents which possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.

Authors+Show Affiliations

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. mrs@medic.upm.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18672036

Citation

Sulaiman, M R., et al. "Evaluation of the Antinociceptive Activity of Ficus Deltoidea Aqueous Extract." Fitoterapia, vol. 79, no. 7-8, 2008, pp. 557-61.
Sulaiman MR, Hussain MK, Zakaria ZA, et al. Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia. 2008;79(7-8):557-61.
Sulaiman, M. R., Hussain, M. K., Zakaria, Z. A., Somchit, M. N., Moin, S., Mohamad, A. S., & Israf, D. A. (2008). Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia, 79(7-8), 557-61. https://doi.org/10.1016/j.fitote.2008.06.005
Sulaiman MR, et al. Evaluation of the Antinociceptive Activity of Ficus Deltoidea Aqueous Extract. Fitoterapia. 2008;79(7-8):557-61. PubMed PMID: 18672036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. AU - Sulaiman,M R, AU - Hussain,M K, AU - Zakaria,Z A, AU - Somchit,M N, AU - Moin,S, AU - Mohamad,A S, AU - Israf,D A, Y1 - 2008/07/10/ PY - 2008/06/11/received PY - 2008/06/18/accepted PY - 2008/8/2/pubmed PY - 2009/3/31/medline PY - 2008/8/2/entrez SP - 557 EP - 61 JF - Fitoterapia JO - Fitoterapia VL - 79 IS - 7-8 N2 - The aqueous extract of Ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. The results of the present study showed that intraperitoneal administration of the F. deltoidea leaves aqueous extract at the dose of 1, 50 and 100 mg/kg, 30 min prior to pain induction produced significant dose-dependent antinociceptive effect in all the models used, which indicating the presence of both central and peripherally mediated activities. Furthermore, the antinociceptive effect of the extract in the formalin and hot plate test was reversed by the non-selective opioid receptor antagonist naloxone suggesting that the endogenous opioid system is involved in its analgesic mechanism of action. Thus, the present results demonstrated that F. deltoidea leaves aqueous extract contains pharmacologically active constituents which possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/18672036/Evaluation_of_the_antinociceptive_activity_of_Ficus_deltoidea_aqueous_extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(08)00160-3 DB - PRIME DP - Unbound Medicine ER -