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Pathogenic mechanisms in endometriosis-associated infertility.
Fertil Steril 2008; 90(2):247-57FS

Abstract

OBJECTIVE

To review the mechanisms by which endometriosis may affect reproductive function.

DESIGN

Review of the English literature from 1986 to 2007 after searching Medline, EMBASE, Cochrane, and BIOSIS, as well as relevant meeting abstracts.

SETTING

Fertility research center and obstetrics and gynecology department in a tertiary care hospital.

RESULT(S)

There is compelling evidence in the literature that endometriosis has detrimental effects on ovarian and tubal function and uterine receptivity, resulting in female infertility. The mechanisms of infertility associated with endometriosis remain controversial and include abnormal folliculogenesis, elevated oxidative stress, altered immune function, and hormonal milieu in the follicular and peritoneal environments, and reduced endometrial receptivity. These factors lead to poor oocyte quality, impaired fertilization, and implantation.

CONCLUSION(S)

Through unraveling the mechanisms by which endometriosis leads to infertility, researchers are sure to find a nonsurgical means to diagnose endometriosis, most likely through serum and peritoneal markers. Cytokines, interleukins, oxidative stress markers, and soluble cellular adhesion molecules all show potential to be used as a reliable marker for diagnosing endometriosis. After analyzing the pathogenic mechanisms of endometriosis, it seems that the future treatment of this entity may include cyclo-oxygenase-2 inhibitors, immunomodulators, or hormonal suppressive therapy to eliminate the need for surgical treatment of endometriosis.

Authors+Show Affiliations

Reproductive Research Center, Department of Obstetrics and Gynecology and Glickman Urological Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18672121

Citation

Gupta, Sajal, et al. "Pathogenic Mechanisms in Endometriosis-associated Infertility." Fertility and Sterility, vol. 90, no. 2, 2008, pp. 247-57.
Gupta S, Goldberg JM, Aziz N, et al. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril. 2008;90(2):247-57.
Gupta, S., Goldberg, J. M., Aziz, N., Goldberg, E., Krajcir, N., & Agarwal, A. (2008). Pathogenic mechanisms in endometriosis-associated infertility. Fertility and Sterility, 90(2), pp. 247-57. doi:10.1016/j.fertnstert.2008.02.093.
Gupta S, et al. Pathogenic Mechanisms in Endometriosis-associated Infertility. Fertil Steril. 2008;90(2):247-57. PubMed PMID: 18672121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenic mechanisms in endometriosis-associated infertility. AU - Gupta,Sajal, AU - Goldberg,Jeffrey M, AU - Aziz,Nabil, AU - Goldberg,Eric, AU - Krajcir,Natalie, AU - Agarwal,Ashok, PY - 2008/02/07/received PY - 2008/02/07/revised PY - 2008/02/07/accepted PY - 2008/8/2/pubmed PY - 2008/8/15/medline PY - 2008/8/2/entrez SP - 247 EP - 57 JF - Fertility and sterility JO - Fertil. Steril. VL - 90 IS - 2 N2 - OBJECTIVE: To review the mechanisms by which endometriosis may affect reproductive function. DESIGN: Review of the English literature from 1986 to 2007 after searching Medline, EMBASE, Cochrane, and BIOSIS, as well as relevant meeting abstracts. SETTING: Fertility research center and obstetrics and gynecology department in a tertiary care hospital. RESULT(S): There is compelling evidence in the literature that endometriosis has detrimental effects on ovarian and tubal function and uterine receptivity, resulting in female infertility. The mechanisms of infertility associated with endometriosis remain controversial and include abnormal folliculogenesis, elevated oxidative stress, altered immune function, and hormonal milieu in the follicular and peritoneal environments, and reduced endometrial receptivity. These factors lead to poor oocyte quality, impaired fertilization, and implantation. CONCLUSION(S): Through unraveling the mechanisms by which endometriosis leads to infertility, researchers are sure to find a nonsurgical means to diagnose endometriosis, most likely through serum and peritoneal markers. Cytokines, interleukins, oxidative stress markers, and soluble cellular adhesion molecules all show potential to be used as a reliable marker for diagnosing endometriosis. After analyzing the pathogenic mechanisms of endometriosis, it seems that the future treatment of this entity may include cyclo-oxygenase-2 inhibitors, immunomodulators, or hormonal suppressive therapy to eliminate the need for surgical treatment of endometriosis. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18672121/Pathogenic_mechanisms_in_endometriosis_associated_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00360-9 DB - PRIME DP - Unbound Medicine ER -