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Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome.
Surg Clin North Am. 2008 Aug; 88(4):819-44, vii.SC

Abstract

Familial colorectal cancer (CRC) accounts for 10% to 20% of all cases of CRC. Two major autosomal dominant forms of heritable CRC are familial adenomatous polyposis (FAP) and Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer). Along with the risk for CRC, both syndromes are associated with elevated risk for other tumors. Improved understanding of the genetic basis of these diseases has not only facilitated the identification and screening of at-risk individuals and the development of prophylactic or early-stage intervention strategies but also provided better insight into sporadic CRC. This article reviews the clinical and genetic characteristics of FAP and Lynch syndrome, recommended screening and surveillance practices, and appropriate surgical and nonsurgical interventions.

Authors+Show Affiliations

Division of General Surgery, Department of Surgery, University of Toronto, 1225-600 University Avenue, Toronto, Ontario, Canada M5G 1X5. wigdan.al.sukhni@utoronto.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18672142

Citation

Al-Sukhni, Wigdan, et al. "Hereditary Colorectal Cancer Syndromes: Familial Adenomatous Polyposis and Lynch Syndrome." The Surgical Clinics of North America, vol. 88, no. 4, 2008, pp. 819-44, vii.
Al-Sukhni W, Aronson M, Gallinger S. Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Surg Clin North Am. 2008;88(4):819-44, vii.
Al-Sukhni, W., Aronson, M., & Gallinger, S. (2008). Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. The Surgical Clinics of North America, 88(4), 819-44, vii. https://doi.org/10.1016/j.suc.2008.04.012
Al-Sukhni W, Aronson M, Gallinger S. Hereditary Colorectal Cancer Syndromes: Familial Adenomatous Polyposis and Lynch Syndrome. Surg Clin North Am. 2008;88(4):819-44, vii. PubMed PMID: 18672142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. AU - Al-Sukhni,Wigdan, AU - Aronson,Melyssa, AU - Gallinger,Steven, PY - 2008/8/2/pubmed PY - 2008/10/1/medline PY - 2008/8/2/entrez SP - 819-44, vii JF - The Surgical clinics of North America JO - Surg. Clin. North Am. VL - 88 IS - 4 N2 - Familial colorectal cancer (CRC) accounts for 10% to 20% of all cases of CRC. Two major autosomal dominant forms of heritable CRC are familial adenomatous polyposis (FAP) and Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer). Along with the risk for CRC, both syndromes are associated with elevated risk for other tumors. Improved understanding of the genetic basis of these diseases has not only facilitated the identification and screening of at-risk individuals and the development of prophylactic or early-stage intervention strategies but also provided better insight into sporadic CRC. This article reviews the clinical and genetic characteristics of FAP and Lynch syndrome, recommended screening and surveillance practices, and appropriate surgical and nonsurgical interventions. SN - 0039-6109 UR - https://www.unboundmedicine.com/medline/citation/18672142/Hereditary_colorectal_cancer_syndromes:_familial_adenomatous_polyposis_and_lynch_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6109(08)00054-6 DB - PRIME DP - Unbound Medicine ER -