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Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery.
J Med Assoc Thai. 2008 May; 91(5):669-74.JM

Abstract

BACKGROUND

Postoperative nausea and vomiting (PONV) remains a very troublesome concomitant phenomenon after general anesthesia. The present study was designed to compare the efficacy and safety of ondansetron with metoclopramide for prophylaxis of PONV in patients undergoing major gynecological surgery.

MATERIAL AND METHOD

A prospective, randomized, double-blind, 382 female patients received either ondansetron 4 mg or metoclopramide 10 mg intravenous administration immediately before the induction of anesthesia. A standard general anesthetic technique was employed throughout. Nausea, vomiting, and safety assessments were performed continuously during the 24 h postoperative period.

RESULTS

Of the 380 patients evaluated, significantly fewer ondansetron 4 mg treated patients (89/189; 47%) experienced postoperative nausea and/or vomiting compared with metoclopramide treated patients (115/ 191; 60%) during the study period (p = 0.007, 95% CI: 1.07, 1.66). Postoperative adverse events were not significantly different between the groups.

CONCLUSION

Prophylactic use of ondansetron is more effective than metoclopramide for preventing PONV in patients undergoing major gynecological surgery.

Authors+Show Affiliations

Division of Anesthesiology, Chaiyaphum Hospital, Chaiyaphum, Thailand. albkb@diamond.mahidol.ac.thNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18672630

Citation

Krobbuaban, Banjong, et al. "Ondansetron Vs. Metoclopramide for the Prevention of Nausea and Vomiting After Gynecologic Surgery." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 91, no. 5, 2008, pp. 669-74.
Krobbuaban B, Pitakpol S, Diregpoke S. Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery. J Med Assoc Thai. 2008;91(5):669-74.
Krobbuaban, B., Pitakpol, S., & Diregpoke, S. (2008). Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 91(5), 669-74.
Krobbuaban B, Pitakpol S, Diregpoke S. Ondansetron Vs. Metoclopramide for the Prevention of Nausea and Vomiting After Gynecologic Surgery. J Med Assoc Thai. 2008;91(5):669-74. PubMed PMID: 18672630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery. AU - Krobbuaban,Banjong, AU - Pitakpol,Samrong, AU - Diregpoke,Siriwan, PY - 2008/8/5/pubmed PY - 2008/9/11/medline PY - 2008/8/5/entrez SP - 669 EP - 74 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 91 IS - 5 N2 - BACKGROUND: Postoperative nausea and vomiting (PONV) remains a very troublesome concomitant phenomenon after general anesthesia. The present study was designed to compare the efficacy and safety of ondansetron with metoclopramide for prophylaxis of PONV in patients undergoing major gynecological surgery. MATERIAL AND METHOD: A prospective, randomized, double-blind, 382 female patients received either ondansetron 4 mg or metoclopramide 10 mg intravenous administration immediately before the induction of anesthesia. A standard general anesthetic technique was employed throughout. Nausea, vomiting, and safety assessments were performed continuously during the 24 h postoperative period. RESULTS: Of the 380 patients evaluated, significantly fewer ondansetron 4 mg treated patients (89/189; 47%) experienced postoperative nausea and/or vomiting compared with metoclopramide treated patients (115/ 191; 60%) during the study period (p = 0.007, 95% CI: 1.07, 1.66). Postoperative adverse events were not significantly different between the groups. CONCLUSION: Prophylactic use of ondansetron is more effective than metoclopramide for preventing PONV in patients undergoing major gynecological surgery. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/18672630/Ondansetron_vs__metoclopramide_for_the_prevention_of_nausea_and_vomiting_after_gynecologic_surgery_ L2 - http://www.diseaseinfosearch.org/result/7414 DB - PRIME DP - Unbound Medicine ER -