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Cell degeneration in alopecia areata. An ultrastructural study.
Am J Dermatopathol. 1991 Jun; 13(3):248-56.AJ

Abstract

The morphology and prevalence of different forms of cell degeneration in hair follicles in acute alopecia areata were investigated. In addition to apoptosis and necrosis, a third morphological pattern of cell degeneration, dark-cell transformation, was evident. Fifteen patients with untreated acute alopecia areata and three normal adults without hair loss were studied. Electron microscopy revealed that although apoptosis of outer root sheath keratinocytes produces normal hair follicle involution (catagen), increased levels of apoptosis, necrosis, and dark-cell formation appear to be related to the pathology of alopecia areata. Although cell degeneration was generally restricted to keratinocytes of the lower follicle, melanocytes, Langerhans' and dermal papilla cells were also affected. Keratinocytic degeneration may affect layers of matrix cells in alopecia areata, unlike the apoptosis of scattered outer root sheath cells in normal catagen. The extent of cell death suggests a pathological rather than a physiological event in alopecia areata.

Authors+Show Affiliations

Unit of Cell Biology, U.M.D.S., London, England.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1867355

Citation

Tobin, D J., et al. "Cell Degeneration in Alopecia Areata. an Ultrastructural Study." The American Journal of Dermatopathology, vol. 13, no. 3, 1991, pp. 248-56.
Tobin DJ, Fenton DA, Kendall MD. Cell degeneration in alopecia areata. An ultrastructural study. Am J Dermatopathol. 1991;13(3):248-56.
Tobin, D. J., Fenton, D. A., & Kendall, M. D. (1991). Cell degeneration in alopecia areata. An ultrastructural study. The American Journal of Dermatopathology, 13(3), 248-56.
Tobin DJ, Fenton DA, Kendall MD. Cell Degeneration in Alopecia Areata. an Ultrastructural Study. Am J Dermatopathol. 1991;13(3):248-56. PubMed PMID: 1867355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell degeneration in alopecia areata. An ultrastructural study. AU - Tobin,D J, AU - Fenton,D A, AU - Kendall,M D, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 248 EP - 56 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 13 IS - 3 N2 - The morphology and prevalence of different forms of cell degeneration in hair follicles in acute alopecia areata were investigated. In addition to apoptosis and necrosis, a third morphological pattern of cell degeneration, dark-cell transformation, was evident. Fifteen patients with untreated acute alopecia areata and three normal adults without hair loss were studied. Electron microscopy revealed that although apoptosis of outer root sheath keratinocytes produces normal hair follicle involution (catagen), increased levels of apoptosis, necrosis, and dark-cell formation appear to be related to the pathology of alopecia areata. Although cell degeneration was generally restricted to keratinocytes of the lower follicle, melanocytes, Langerhans' and dermal papilla cells were also affected. Keratinocytic degeneration may affect layers of matrix cells in alopecia areata, unlike the apoptosis of scattered outer root sheath cells in normal catagen. The extent of cell death suggests a pathological rather than a physiological event in alopecia areata. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/1867355/Cell_degeneration_in_alopecia_areata__An_ultrastructural_study_ DB - PRIME DP - Unbound Medicine ER -