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The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents.
Neuropharmacology. 2008 Oct; 55(5):908-18.N

Abstract

The present study investigated the putative pro-cognitive effects of the novel selective PDE9 inhibitor BAY 73-6691. The effects on basal synaptic transmission and long-term potentiation (LTP) were investigated in rat hippocampal slices. Pro-cognitive effects were assessed in a series of learning and memory tasks using rodents as subjects. BAY 73-6691 had no effect on basal synaptic transmission in hippocampal slices prepared from young adult (7- to 8-week-old) Wistar rats. A dose of 10 microM, but not 30 microM, BAY 73-6691 enhanced early LTP after weak tetanic stimulation. The dose effective in young adult Wistar rats did not affect LTP in hippocampal slices prepared from young (7- to 8-week-old) Fischer 344 X Brown Norway (FBNF1) rats, probably reflecting strain differences. However, it increased basal synaptic transmission and enhanced early LTP after weak tetanic stimulation in hippocampal slices prepared from very old (31- to 35-month-old) FBNF1 rats. BAY 73-6691 enhanced acquisition, consolidation, and retention of long-term memory (LTM) in a social recognition task and tended to enhance LTM in an object recognition task. Bay 73-6691 attenuated the scoplamine-induced retention deficit in a passive avoidance task, and the MK-801-induced short-term memory deficits in a T-maze alternation task. The mechanism of action, possibly through modulation of the NO/cGMP-PKG/CREB pathway, is discussed. Our findings support the notion that PDE9 inhibition may be a novel target for treating memory deficits that are associated with aging and neurodegenerative disorders such as Alzheimer's disease.

Authors+Show Affiliations

BAYER HealthCare AG, Global Drug Discovery, Department of CNS Research, D-42096 Wuppertal-Elberfeld, Germany. f.j.vanderstaay@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18674549

Citation

van der Staay, F Josef, et al. "The Novel Selective PDE9 Inhibitor BAY 73-6691 Improves Learning and Memory in Rodents." Neuropharmacology, vol. 55, no. 5, 2008, pp. 908-18.
van der Staay FJ, Rutten K, Bärfacker L, et al. The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology. 2008;55(5):908-18.
van der Staay, F. J., Rutten, K., Bärfacker, L., Devry, J., Erb, C., Heckroth, H., Karthaus, D., Tersteegen, A., van Kampen, M., Blokland, A., Prickaerts, J., Reymann, K. G., Schröder, U. H., & Hendrix, M. (2008). The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology, 55(5), 908-18. https://doi.org/10.1016/j.neuropharm.2008.07.005
van der Staay FJ, et al. The Novel Selective PDE9 Inhibitor BAY 73-6691 Improves Learning and Memory in Rodents. Neuropharmacology. 2008;55(5):908-18. PubMed PMID: 18674549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. AU - van der Staay,F Josef, AU - Rutten,Kris, AU - Bärfacker,Lars, AU - Devry,Jean, AU - Erb,Christina, AU - Heckroth,Heike, AU - Karthaus,Dagmar, AU - Tersteegen,Adrian, AU - van Kampen,Marja, AU - Blokland,Arjan, AU - Prickaerts,Jos, AU - Reymann,Klaus G, AU - Schröder,Ulrich H, AU - Hendrix,Martin, Y1 - 2008/07/12/ PY - 2007/11/21/received PY - 2008/07/01/revised PY - 2008/07/04/accepted PY - 2008/8/5/pubmed PY - 2009/1/16/medline PY - 2008/8/5/entrez SP - 908 EP - 18 JF - Neuropharmacology JO - Neuropharmacology VL - 55 IS - 5 N2 - The present study investigated the putative pro-cognitive effects of the novel selective PDE9 inhibitor BAY 73-6691. The effects on basal synaptic transmission and long-term potentiation (LTP) were investigated in rat hippocampal slices. Pro-cognitive effects were assessed in a series of learning and memory tasks using rodents as subjects. BAY 73-6691 had no effect on basal synaptic transmission in hippocampal slices prepared from young adult (7- to 8-week-old) Wistar rats. A dose of 10 microM, but not 30 microM, BAY 73-6691 enhanced early LTP after weak tetanic stimulation. The dose effective in young adult Wistar rats did not affect LTP in hippocampal slices prepared from young (7- to 8-week-old) Fischer 344 X Brown Norway (FBNF1) rats, probably reflecting strain differences. However, it increased basal synaptic transmission and enhanced early LTP after weak tetanic stimulation in hippocampal slices prepared from very old (31- to 35-month-old) FBNF1 rats. BAY 73-6691 enhanced acquisition, consolidation, and retention of long-term memory (LTM) in a social recognition task and tended to enhance LTM in an object recognition task. Bay 73-6691 attenuated the scoplamine-induced retention deficit in a passive avoidance task, and the MK-801-induced short-term memory deficits in a T-maze alternation task. The mechanism of action, possibly through modulation of the NO/cGMP-PKG/CREB pathway, is discussed. Our findings support the notion that PDE9 inhibition may be a novel target for treating memory deficits that are associated with aging and neurodegenerative disorders such as Alzheimer's disease. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/18674549/The_novel_selective_PDE9_inhibitor_BAY_73_6691_improves_learning_and_memory_in_rodents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(08)00278-5 DB - PRIME DP - Unbound Medicine ER -