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(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.
Neuropharmacology. 2008 Dec; 55(7):1121-30.N

Abstract

3,4-Methlylenedioxymethamphetamine (MDMA) administration (4 x 15 mg/kg) on a single day has been shown to cause path integration deficits in rats. While most animal experiments focus on single binge-type models of MDMA use, many MDMA users take the drug on a recurring basis. The purpose of this study was to compare the effects of repeated single-day treatments with MDMA (4 x 15 mg/kg) once weekly for 5 weeks to animals that only received MDMA on week 5 and saline on weeks 1-4. In animals treated with MDMA for 5 weeks, there was an increase in time spent in the open area of the elevated zero maze suggesting a decrease in anxiety or increase in impulsivity compared to the animals given MDMA for 1 week and saline treated controls. Regardless of dosing regimen, MDMA treatment produced path integration deficits as evidenced by an increase in latency to find the goal in the Cincinnati water maze. Animals treated with MDMA also showed a transient hypoactivity that was not present when the animals were re-tested at the end of cognitive testing. In addition, both MDMA-treated groups showed comparable hyperactive responses to a later methamphetamine challenge. No differences were observed in spatial learning in the Morris water maze during acquisition or reversal but MDMA-related deficits were seen on reduced platform-size trials. Taken together, the data show that a single-day regimen of MDMA induces deficits similar to that of multiple weekly treatments.

Authors+Show Affiliations

Division of Neurology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18674550

Citation

Skelton, Matthew R., et al. "(+/-)-3,4-Methylenedioxymethamphetamine Treatment in Adult Rats Impairs Path Integration Learning: a Comparison of Single Vs once Per Week Treatment for 5 Weeks." Neuropharmacology, vol. 55, no. 7, 2008, pp. 1121-30.
Skelton MR, Able JA, Grace CE, et al. (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology. 2008;55(7):1121-30.
Skelton, M. R., Able, J. A., Grace, C. E., Herring, N. R., Schaefer, T. L., Gudelsky, G. A., Vorhees, C. V., & Williams, M. T. (2008). (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology, 55(7), 1121-30. https://doi.org/10.1016/j.neuropharm.2008.07.006
Skelton MR, et al. (+/-)-3,4-Methylenedioxymethamphetamine Treatment in Adult Rats Impairs Path Integration Learning: a Comparison of Single Vs once Per Week Treatment for 5 Weeks. Neuropharmacology. 2008;55(7):1121-30. PubMed PMID: 18674550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. AU - Skelton,Matthew R, AU - Able,Jessica A, AU - Grace,Curtis E, AU - Herring,Nicole R, AU - Schaefer,Tori L, AU - Gudelsky,Gary A, AU - Vorhees,Charles V, AU - Williams,Michael T, Y1 - 2008/07/12/ PY - 2007/12/14/received PY - 2008/06/25/revised PY - 2008/07/04/accepted PY - 2008/8/5/pubmed PY - 2009/1/27/medline PY - 2008/8/5/entrez SP - 1121 EP - 30 JF - Neuropharmacology JO - Neuropharmacology VL - 55 IS - 7 N2 - 3,4-Methlylenedioxymethamphetamine (MDMA) administration (4 x 15 mg/kg) on a single day has been shown to cause path integration deficits in rats. While most animal experiments focus on single binge-type models of MDMA use, many MDMA users take the drug on a recurring basis. The purpose of this study was to compare the effects of repeated single-day treatments with MDMA (4 x 15 mg/kg) once weekly for 5 weeks to animals that only received MDMA on week 5 and saline on weeks 1-4. In animals treated with MDMA for 5 weeks, there was an increase in time spent in the open area of the elevated zero maze suggesting a decrease in anxiety or increase in impulsivity compared to the animals given MDMA for 1 week and saline treated controls. Regardless of dosing regimen, MDMA treatment produced path integration deficits as evidenced by an increase in latency to find the goal in the Cincinnati water maze. Animals treated with MDMA also showed a transient hypoactivity that was not present when the animals were re-tested at the end of cognitive testing. In addition, both MDMA-treated groups showed comparable hyperactive responses to a later methamphetamine challenge. No differences were observed in spatial learning in the Morris water maze during acquisition or reversal but MDMA-related deficits were seen on reduced platform-size trials. Taken together, the data show that a single-day regimen of MDMA induces deficits similar to that of multiple weekly treatments. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/18674550/_+/___34_Methylenedioxymethamphetamine_treatment_in_adult_rats_impairs_path_integration_learning:_a_comparison_of_single_vs_once_per_week_treatment_for_5_weeks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(08)00279-7 DB - PRIME DP - Unbound Medicine ER -