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Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study.
Reg Anesth Pain Med 2008 Jul-Aug; 33(4):332-9RA

Abstract

BACKGROUND AND OBJECTIVES

Side effects of spinal anesthesia include arterial hypotension and bradycardia. Both of them may be induced by sympathetic nerve blockade as well as by the Bezold-Jarisch reflex, which may be mediated by peripheral serotonin receptors (5-HT(3) type). The aim of this study was to verify the hypothesis that blockade of type 3 serotonin receptors by intravenous ondansetron administration might reduce hypotension and bradycardia induced by spinal anesthesia.

METHODS

Seventy-one patients participated in the study; 36 in the ondansetron group (receiving 8 mg intravenous ondansetron), and 35 in the placebo group (receiving isotonic NaCl solution). Measurements of heart rate and arterial blood pressure were taken every 5 minutes after spinal anesthesia was performed with 4 mL 0.5% hyperbaric bupivacaine solution.

RESULTS

Decreases in mean, systolic, and diastolic arterial pressure as well as in heart rate, compared with baseline values were observed in both groups. Minimal systolic and mean blood pressure values obtained over a 20-minute observation period were significantly higher in the ondansetron group. There were no significant differences in diastolic blood pressure and heart rate values between the groups.

CONCLUSIONS

Ondansetron given intravenously attenuates the fall of systolic and mean blood pressure, but does not have an influence on diastolic blood pressure or heart rate.

Authors+Show Affiliations

Department of Anaesthesiology and Intensive Therapy, Medical University of Gdansk, Gdansk, Poland. r.owczuk@amg.gda.pl <r.owczuk@amg.gda.pl>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18675744

Citation

Owczuk, Radoslaw, et al. "Ondansetron Given Intravenously Attenuates Arterial Blood Pressure Drop Due to Spinal Anesthesia: a Double-blind, Placebo-controlled Study." Regional Anesthesia and Pain Medicine, vol. 33, no. 4, 2008, pp. 332-9.
Owczuk R, Wenski W, Polak-Krzeminska A, et al. Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. Reg Anesth Pain Med. 2008;33(4):332-9.
Owczuk, R., Wenski, W., Polak-Krzeminska, A., Twardowski, P., Arszułowicz, R., Dylczyk-Sommer, A., ... Wujtewicz, M. (2008). Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. Regional Anesthesia and Pain Medicine, 33(4), pp. 332-9. doi:10.1016/j.rapm.2008.01.010.
Owczuk R, et al. Ondansetron Given Intravenously Attenuates Arterial Blood Pressure Drop Due to Spinal Anesthesia: a Double-blind, Placebo-controlled Study. Reg Anesth Pain Med. 2008;33(4):332-9. PubMed PMID: 18675744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. AU - Owczuk,Radoslaw, AU - Wenski,Wojciech, AU - Polak-Krzeminska,Agnieszka, AU - Twardowski,Pawel, AU - Arszułowicz,Renata, AU - Dylczyk-Sommer,Anna, AU - Wujtewicz,Magdalena A, AU - Sawicka,Wioletta, AU - Morzuch,Ewa, AU - Smietanski,Maciej, AU - Wujtewicz,Maria, PY - 2007/11/11/received PY - 2008/01/18/revised PY - 2008/01/18/accepted PY - 2008/8/5/pubmed PY - 2008/10/15/medline PY - 2008/8/5/entrez SP - 332 EP - 9 JF - Regional anesthesia and pain medicine JO - Reg Anesth Pain Med VL - 33 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Side effects of spinal anesthesia include arterial hypotension and bradycardia. Both of them may be induced by sympathetic nerve blockade as well as by the Bezold-Jarisch reflex, which may be mediated by peripheral serotonin receptors (5-HT(3) type). The aim of this study was to verify the hypothesis that blockade of type 3 serotonin receptors by intravenous ondansetron administration might reduce hypotension and bradycardia induced by spinal anesthesia. METHODS: Seventy-one patients participated in the study; 36 in the ondansetron group (receiving 8 mg intravenous ondansetron), and 35 in the placebo group (receiving isotonic NaCl solution). Measurements of heart rate and arterial blood pressure were taken every 5 minutes after spinal anesthesia was performed with 4 mL 0.5% hyperbaric bupivacaine solution. RESULTS: Decreases in mean, systolic, and diastolic arterial pressure as well as in heart rate, compared with baseline values were observed in both groups. Minimal systolic and mean blood pressure values obtained over a 20-minute observation period were significantly higher in the ondansetron group. There were no significant differences in diastolic blood pressure and heart rate values between the groups. CONCLUSIONS: Ondansetron given intravenously attenuates the fall of systolic and mean blood pressure, but does not have an influence on diastolic blood pressure or heart rate. SN - 1532-8651 UR - https://www.unboundmedicine.com/medline/citation/18675744/Ondansetron_given_intravenously_attenuates_arterial_blood_pressure_drop_due_to_spinal_anesthesia:_a_double_blind_placebo_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1098-7339(08)00123-5 DB - PRIME DP - Unbound Medicine ER -