Tags

Type your tag names separated by a space and hit enter

Comparison of luteal estradiol patch and gonadotropin-releasing hormone antagonist suppression protocol before gonadotropin stimulation versus microdose gonadotropin-releasing hormone agonist protocol for patients with a history of poor in vitro fertilization outcomes.
Fertil Steril. 2009 Jul; 92(1):226-30.FS

Abstract

OBJECTIVE

To compare IVF outcomes in poor-responder patients undergoing stimulation after luteal phase E(2) patch/GnRH antagonist (LPG) protocol versus microdose GnRH agonist protocol.

DESIGN

Retrospective analysis.

SETTING

University-based IVF center.

PATIENT(S)

Forty-five women undergoing ovarian stimulation for IVF using the LPG protocol were compared with 76 women stimulated with the microdose GnRH agonist protocol from May 2005 to April 2006.

MAIN OUTCOME MEASURE(S)

Cancellation rate, number of oocytes retrieved, and clinical pregnancy rates.

RESULT(S)

The mean number of oocytes (9.1 +/- 4.1 vs. 8.9 +/- 4.3) and mature oocytes (6.7 +/- 3.5 vs. 6.8 +/- 3.1) retrieved were similar, as were the fertilization rates (70.0% +/- 24.2% vs. 69.9% +/- 21.5%) and the number of embryos transferred (2.5 +/- 1.1 vs. 2.7 +/- 1.3). The cancellation rate was not significantly different between the groups (13/45, 28.9% vs. 23/76, 30.3%). Likewise, there were no significant differences among the implantation rate (15.0% vs. 12.5%), clinical pregnancy rate (43.3% vs. 45.1%), and ongoing pregnancy rate per transfer (33.3% vs. 26.0%) between both groups.

CONCLUSION(S)

This study demonstrates that the use of an E(2) patch and a GnRH antagonist during the preceding luteal phase in patients with a history of failed cycles can provide similar IVF outcomes when compared with the microdose GnRH agonist protocol.

Authors+Show Affiliations

Center for Advanced Reproductive Services, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6224, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18675961

Citation

Weitzman, Vanessa N., et al. "Comparison of Luteal Estradiol Patch and Gonadotropin-releasing Hormone Antagonist Suppression Protocol Before Gonadotropin Stimulation Versus Microdose Gonadotropin-releasing Hormone Agonist Protocol for Patients With a History of Poor in Vitro Fertilization Outcomes." Fertility and Sterility, vol. 92, no. 1, 2009, pp. 226-30.
Weitzman VN, Engmann L, DiLuigi A, et al. Comparison of luteal estradiol patch and gonadotropin-releasing hormone antagonist suppression protocol before gonadotropin stimulation versus microdose gonadotropin-releasing hormone agonist protocol for patients with a history of poor in vitro fertilization outcomes. Fertil Steril. 2009;92(1):226-30.
Weitzman, V. N., Engmann, L., DiLuigi, A., Maier, D., Nulsen, J., & Benadiva, C. (2009). Comparison of luteal estradiol patch and gonadotropin-releasing hormone antagonist suppression protocol before gonadotropin stimulation versus microdose gonadotropin-releasing hormone agonist protocol for patients with a history of poor in vitro fertilization outcomes. Fertility and Sterility, 92(1), 226-30. https://doi.org/10.1016/j.fertnstert.2008.04.024
Weitzman VN, et al. Comparison of Luteal Estradiol Patch and Gonadotropin-releasing Hormone Antagonist Suppression Protocol Before Gonadotropin Stimulation Versus Microdose Gonadotropin-releasing Hormone Agonist Protocol for Patients With a History of Poor in Vitro Fertilization Outcomes. Fertil Steril. 2009;92(1):226-30. PubMed PMID: 18675961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of luteal estradiol patch and gonadotropin-releasing hormone antagonist suppression protocol before gonadotropin stimulation versus microdose gonadotropin-releasing hormone agonist protocol for patients with a history of poor in vitro fertilization outcomes. AU - Weitzman,Vanessa N, AU - Engmann,Lawrence, AU - DiLuigi,Andrea, AU - Maier,Donald, AU - Nulsen,John, AU - Benadiva,Claudio, Y1 - 2008/08/03/ PY - 2008/01/04/received PY - 2008/04/11/revised PY - 2008/04/11/accepted PY - 2008/8/5/pubmed PY - 2009/7/30/medline PY - 2008/8/5/entrez SP - 226 EP - 30 JF - Fertility and sterility JO - Fertil Steril VL - 92 IS - 1 N2 - OBJECTIVE: To compare IVF outcomes in poor-responder patients undergoing stimulation after luteal phase E(2) patch/GnRH antagonist (LPG) protocol versus microdose GnRH agonist protocol. DESIGN: Retrospective analysis. SETTING: University-based IVF center. PATIENT(S): Forty-five women undergoing ovarian stimulation for IVF using the LPG protocol were compared with 76 women stimulated with the microdose GnRH agonist protocol from May 2005 to April 2006. MAIN OUTCOME MEASURE(S): Cancellation rate, number of oocytes retrieved, and clinical pregnancy rates. RESULT(S): The mean number of oocytes (9.1 +/- 4.1 vs. 8.9 +/- 4.3) and mature oocytes (6.7 +/- 3.5 vs. 6.8 +/- 3.1) retrieved were similar, as were the fertilization rates (70.0% +/- 24.2% vs. 69.9% +/- 21.5%) and the number of embryos transferred (2.5 +/- 1.1 vs. 2.7 +/- 1.3). The cancellation rate was not significantly different between the groups (13/45, 28.9% vs. 23/76, 30.3%). Likewise, there were no significant differences among the implantation rate (15.0% vs. 12.5%), clinical pregnancy rate (43.3% vs. 45.1%), and ongoing pregnancy rate per transfer (33.3% vs. 26.0%) between both groups. CONCLUSION(S): This study demonstrates that the use of an E(2) patch and a GnRH antagonist during the preceding luteal phase in patients with a history of failed cycles can provide similar IVF outcomes when compared with the microdose GnRH agonist protocol. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18675961/Comparison_of_luteal_estradiol_patch_and_gonadotropin_releasing_hormone_antagonist_suppression_protocol_before_gonadotropin_stimulation_versus_microdose_gonadotropin_releasing_hormone_agonist_protocol_for_patients_with_a_history_of_poor_in_vitro_fertilization_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00891-1 DB - PRIME DP - Unbound Medicine ER -