Tags

Type your tag names separated by a space and hit enter

Clinical subsequent fractures cluster in time after first fractures.
Ann Rheum Dis. 2009 Jan; 68(1):99-102.AR

Abstract

OBJECTIVES

The risk of subsequent fractures is double the risk of having a first fracture. We analysed whether this risk is constant or not over time.

METHODS

A population-based study in 4140 postmenopausal women, aged between 50 and 90 years, on radiographic confirmed clinical fractures from menopause onwards analysed by Cox regression.

RESULTS

A total of 924 (22%) women had a first fracture and 243 (26% of 924) a subsequent fracture. Of all first fractures, 4% occurred in each year from menopause onwards, while after a first fracture 23% of all subsequent fractures occurred within 1 year and 54% within 5 years. When calculated from time of first fracture, the relative risk (RR) of subsequent fracture was 2.1 (95% CI 1.7 to 2.6) and remained increased over 15 years. When calculated for specific time intervals after a first fracture, the RR was 5.3 (95% CI 4.0 to 6.6) within 1 year, 2.8 (95% CI 2.0 to 3.6) within 2-5 years, 1.4 (95% CI 1.0 to 1.8) within 6-10 years and 0.41 (95% CI 0.29 to 0.53) after >10 years.

CONCLUSIONS

From menopause onwards, clinical fractures cluster in time, indicating the need for early action to prevent subsequent fractures.

Authors+Show Affiliations

Maastricht University, Department of General Practice, PO Box 616, 6200 MD, Maastricht, The Netherlands. t.vangeel@hag.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18677009

Citation

van Geel, T A C M., et al. "Clinical Subsequent Fractures Cluster in Time After First Fractures." Annals of the Rheumatic Diseases, vol. 68, no. 1, 2009, pp. 99-102.
van Geel TA, van Helden S, Geusens PP, et al. Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis. 2009;68(1):99-102.
van Geel, T. A., van Helden, S., Geusens, P. P., Winkens, B., & Dinant, G. J. (2009). Clinical subsequent fractures cluster in time after first fractures. Annals of the Rheumatic Diseases, 68(1), 99-102. https://doi.org/10.1136/ard.2008.092775
van Geel TA, et al. Clinical Subsequent Fractures Cluster in Time After First Fractures. Ann Rheum Dis. 2009;68(1):99-102. PubMed PMID: 18677009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical subsequent fractures cluster in time after first fractures. AU - van Geel,T A C M, AU - van Helden,S, AU - Geusens,P P, AU - Winkens,B, AU - Dinant,G-J, Y1 - 2008/08/03/ PY - 2008/8/5/entrez PY - 2008/8/5/pubmed PY - 2009/1/27/medline SP - 99 EP - 102 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 68 IS - 1 N2 - OBJECTIVES: The risk of subsequent fractures is double the risk of having a first fracture. We analysed whether this risk is constant or not over time. METHODS: A population-based study in 4140 postmenopausal women, aged between 50 and 90 years, on radiographic confirmed clinical fractures from menopause onwards analysed by Cox regression. RESULTS: A total of 924 (22%) women had a first fracture and 243 (26% of 924) a subsequent fracture. Of all first fractures, 4% occurred in each year from menopause onwards, while after a first fracture 23% of all subsequent fractures occurred within 1 year and 54% within 5 years. When calculated from time of first fracture, the relative risk (RR) of subsequent fracture was 2.1 (95% CI 1.7 to 2.6) and remained increased over 15 years. When calculated for specific time intervals after a first fracture, the RR was 5.3 (95% CI 4.0 to 6.6) within 1 year, 2.8 (95% CI 2.0 to 3.6) within 2-5 years, 1.4 (95% CI 1.0 to 1.8) within 6-10 years and 0.41 (95% CI 0.29 to 0.53) after >10 years. CONCLUSIONS: From menopause onwards, clinical fractures cluster in time, indicating the need for early action to prevent subsequent fractures. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/18677009/Clinical_subsequent_fractures_cluster_in_time_after_first_fractures_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=18677009 DB - PRIME DP - Unbound Medicine ER -