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Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis.
Eur J Gastroenterol Hepatol 2008; 20(7):674-9EJ

Abstract

AIM

Alcohol drinking, cigarette smoking, and diabetes have been claimed as risk factors for hepatocellular carcinoma in case-control studies. The aim of this study was to define the impact of these risk factors on the development of hepatocellular carcinoma in hepatitis C virus-related liver cirrhosis.

METHODS

A historical cohort of 138 patients with posttransfusion hepatitis C virus-related cirrhosis was selected by reviewing all files of patients referred to our liver unit. Sixty-three of them (46%) developed hepatocellular carcinoma.

RESULTS

At univariate analysis, risk factors for hepatocellular carcinoma were observed in patients aged above 59 years [P=0.004; relative risk (RR): 2.08, 95% confidence interval (CI): 1.19-3.68], male sex (P<0.001; RR: 2.48, 95% CI: 1.59-3.87), habit of alcohol drinking (P=0.001; RR: 1.89, 95% CI: 1.24-2.88), and duration of alcohol consumption of more than 30 years (P=0.02; RR: 2.08, 95% CI: 0.98-4.40). At Cox regression analysis, only male sex was an independent predictive factor (beta=0.86; P=0.002; hazard ratio=2.4, 95% CI: 1.3-4.1).

CONCLUSION

Diabetes, smoking, and alcohol drinking were not independently related to the risk of developing hepatocellular carcinoma in hepatitis C virus-related cirrhosis.

Authors+Show Affiliations

Division of Hepatology, Cardarelli Hospital, Napoli, Italy. ggdicostanzo@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18679071

Citation

Di Costanzo, Giovan Giuseppe, et al. "Effect of Alcohol, Cigarette Smoking, and Diabetes On Occurrence of Hepatocellular Carcinoma in Patients With Transfusion-acquired Hepatitis C Virus Infection Who Develop Cirrhosis." European Journal of Gastroenterology & Hepatology, vol. 20, no. 7, 2008, pp. 674-9.
Di Costanzo GG, De Luca M, Tritto G, et al. Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis. Eur J Gastroenterol Hepatol. 2008;20(7):674-9.
Di Costanzo, G. G., De Luca, M., Tritto, G., Lampasi, F., Addario, L., Lanza, A. G., ... Ascione, A. (2008). Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis. European Journal of Gastroenterology & Hepatology, 20(7), pp. 674-9. doi:10.1097/MEG.0b013e3282f762e1.
Di Costanzo GG, et al. Effect of Alcohol, Cigarette Smoking, and Diabetes On Occurrence of Hepatocellular Carcinoma in Patients With Transfusion-acquired Hepatitis C Virus Infection Who Develop Cirrhosis. Eur J Gastroenterol Hepatol. 2008;20(7):674-9. PubMed PMID: 18679071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis. AU - Di Costanzo,Giovan Giuseppe, AU - De Luca,Massimo, AU - Tritto,Giovanni, AU - Lampasi,Filippo, AU - Addario,Luigi, AU - Lanza,Alfonso Galeota, AU - Tartaglione,Maria Teresa, AU - Picciotto,Francesco Paolo, AU - Ascione,Antonio, PY - 2008/8/6/pubmed PY - 2009/3/17/medline PY - 2008/8/6/entrez SP - 674 EP - 9 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 20 IS - 7 N2 - AIM: Alcohol drinking, cigarette smoking, and diabetes have been claimed as risk factors for hepatocellular carcinoma in case-control studies. The aim of this study was to define the impact of these risk factors on the development of hepatocellular carcinoma in hepatitis C virus-related liver cirrhosis. METHODS: A historical cohort of 138 patients with posttransfusion hepatitis C virus-related cirrhosis was selected by reviewing all files of patients referred to our liver unit. Sixty-three of them (46%) developed hepatocellular carcinoma. RESULTS: At univariate analysis, risk factors for hepatocellular carcinoma were observed in patients aged above 59 years [P=0.004; relative risk (RR): 2.08, 95% confidence interval (CI): 1.19-3.68], male sex (P<0.001; RR: 2.48, 95% CI: 1.59-3.87), habit of alcohol drinking (P=0.001; RR: 1.89, 95% CI: 1.24-2.88), and duration of alcohol consumption of more than 30 years (P=0.02; RR: 2.08, 95% CI: 0.98-4.40). At Cox regression analysis, only male sex was an independent predictive factor (beta=0.86; P=0.002; hazard ratio=2.4, 95% CI: 1.3-4.1). CONCLUSION: Diabetes, smoking, and alcohol drinking were not independently related to the risk of developing hepatocellular carcinoma in hepatitis C virus-related cirrhosis. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/18679071/Effect_of_alcohol_cigarette_smoking_and_diabetes_on_occurrence_of_hepatocellular_carcinoma_in_patients_with_transfusion_acquired_hepatitis_C_virus_infection_who_develop_cirrhosis_ L2 - http://dx.doi.org/10.1097/MEG.0b013e3282f762e1 DB - PRIME DP - Unbound Medicine ER -