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Tissue oxygenation during management of cerebral perfusion pressure with phenylephrine or vasopressin.
Crit Care Med. 2008 Sep; 36(9):2641-50.CC

Abstract

OBJECTIVE

Phenylephrine is often used for management of cerebral perfusion pressure after traumatic brain injury, but can have undesirable actions. Few studies have evaluated alternatives. The hypothesis was that arginine vasopressin was as effective as phenylephrine for maintaining tissue oxygenation during cerebral perfusion pressure management.

DESIGN

Prospective randomized, blinded animal study.

SETTING

University laboratory.

SUBJECTS

Thirty-five anesthetized swine (46 +/- 1 kg).

INTERVENTIONS

Blunt trauma to the head and bilateral chests (estimated injury severity score was 25-32) was followed by hypoventilation. Resuscitation was divided into phases to simulate treatment in a typical prehospital, emergency room, and intensive care unit. For 30-45 mins postinjury, 1 L of normal saline was administered. For 45-120 mins, normal saline maintained systolic blood pressure >100 mm Hg plus mannitol for intracranial hypertension. After 120 mins, phenylephrine or arginine vasopressin was titrated to cerebral perfusion pressure >70 mm Hg (randomized and blinded) plus normal saline to maintain filling pressure >12 mm Hg plus glucose to maintain normoglycemia.

MEASUREMENTS AND MAIN RESULTS

Mortality rate was 37% (13 of 35) within 2 hrs. Before resuscitation, mean arterial pressure was 61 +/- 5 mm Hg, heart rate was 110 +/- 6 beats/min, PaO2 was 46 +/- 2 mm Hg, and lactate was 5.0 +/- 0.4 mM. Intracranial pressure increased from 8 +/- 1 mm Hg to 20 +/- 1 mm Hg and brain tissue PO2 decreased from 19 +/- 1 mm Hg to 8 +/- 1 mm Hg. Resuscitation corrected most variables, as well as mixed venous, renal, portal, and muscle oxygen saturations, but 90% (20 of 22) required pressor support. After 6 hrs with either pressor, hemodynamics were stable. However, with phenylephrine vs. arginine vasopressin, intracranial pressure averaged >10 mm Hg higher and brain tissue PO2 was 6 mm Hg lower, whereas tissue oxygen saturations were >10% higher in the shoulder and hindlimb muscles (all p < 0.05).

CONCLUSIONS

Arginine vasopressin was as effective as phenylephrine for maintaining cerebral perfusion pressure, but intracranial pressure and brain tissue oxygenation were improved at the expense of the periphery.

Authors+Show Affiliations

Dewitt-Daughtry Family Department of Surgery, Division of Trauma, University of Miami Miller School of Medicine, Miami, FL, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18679110

Citation

Dudkiewicz, Michael, and Kenneth G. Proctor. "Tissue Oxygenation During Management of Cerebral Perfusion Pressure With Phenylephrine or Vasopressin." Critical Care Medicine, vol. 36, no. 9, 2008, pp. 2641-50.
Dudkiewicz M, Proctor KG. Tissue oxygenation during management of cerebral perfusion pressure with phenylephrine or vasopressin. Crit Care Med. 2008;36(9):2641-50.
Dudkiewicz, M., & Proctor, K. G. (2008). Tissue oxygenation during management of cerebral perfusion pressure with phenylephrine or vasopressin. Critical Care Medicine, 36(9), 2641-50. https://doi.org/10.1097/CCM.0b013e3181847af3
Dudkiewicz M, Proctor KG. Tissue Oxygenation During Management of Cerebral Perfusion Pressure With Phenylephrine or Vasopressin. Crit Care Med. 2008;36(9):2641-50. PubMed PMID: 18679110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue oxygenation during management of cerebral perfusion pressure with phenylephrine or vasopressin. AU - Dudkiewicz,Michael, AU - Proctor,Kenneth G, PY - 2008/8/6/pubmed PY - 2008/10/3/medline PY - 2008/8/6/entrez SP - 2641 EP - 50 JF - Critical care medicine JO - Crit Care Med VL - 36 IS - 9 N2 - OBJECTIVE: Phenylephrine is often used for management of cerebral perfusion pressure after traumatic brain injury, but can have undesirable actions. Few studies have evaluated alternatives. The hypothesis was that arginine vasopressin was as effective as phenylephrine for maintaining tissue oxygenation during cerebral perfusion pressure management. DESIGN: Prospective randomized, blinded animal study. SETTING: University laboratory. SUBJECTS: Thirty-five anesthetized swine (46 +/- 1 kg). INTERVENTIONS: Blunt trauma to the head and bilateral chests (estimated injury severity score was 25-32) was followed by hypoventilation. Resuscitation was divided into phases to simulate treatment in a typical prehospital, emergency room, and intensive care unit. For 30-45 mins postinjury, 1 L of normal saline was administered. For 45-120 mins, normal saline maintained systolic blood pressure >100 mm Hg plus mannitol for intracranial hypertension. After 120 mins, phenylephrine or arginine vasopressin was titrated to cerebral perfusion pressure >70 mm Hg (randomized and blinded) plus normal saline to maintain filling pressure >12 mm Hg plus glucose to maintain normoglycemia. MEASUREMENTS AND MAIN RESULTS: Mortality rate was 37% (13 of 35) within 2 hrs. Before resuscitation, mean arterial pressure was 61 +/- 5 mm Hg, heart rate was 110 +/- 6 beats/min, PaO2 was 46 +/- 2 mm Hg, and lactate was 5.0 +/- 0.4 mM. Intracranial pressure increased from 8 +/- 1 mm Hg to 20 +/- 1 mm Hg and brain tissue PO2 decreased from 19 +/- 1 mm Hg to 8 +/- 1 mm Hg. Resuscitation corrected most variables, as well as mixed venous, renal, portal, and muscle oxygen saturations, but 90% (20 of 22) required pressor support. After 6 hrs with either pressor, hemodynamics were stable. However, with phenylephrine vs. arginine vasopressin, intracranial pressure averaged >10 mm Hg higher and brain tissue PO2 was 6 mm Hg lower, whereas tissue oxygen saturations were >10% higher in the shoulder and hindlimb muscles (all p < 0.05). CONCLUSIONS: Arginine vasopressin was as effective as phenylephrine for maintaining cerebral perfusion pressure, but intracranial pressure and brain tissue oxygenation were improved at the expense of the periphery. SN - 1530-0293 UR - https://www.unboundmedicine.com/medline/citation/18679110/Tissue_oxygenation_during_management_of_cerebral_perfusion_pressure_with_phenylephrine_or_vasopressin_ L2 - https://dx.doi.org/10.1097/CCM.0b013e3181847af3 DB - PRIME DP - Unbound Medicine ER -