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Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets.
Pediatr Res 2008; 64(6):653-8PR

Abstract

To test the neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol (CBD), piglets received i.v. CBD or vehicle after hypoxia-ischemia (HI: temporary occlusion of both carotid arteries plus hypoxia). Nonhypoxic-ischemic sham-operated piglets remained as controls. Brain damage was studied by near-infrared spectroscopy (NIRS) and amplitude-integrated electroencephalography (aEEG) and by histologic assessment (Nissl and FluoroJadeB staining). In HI+vehicle, HI led to severe cerebral hemodynamic and metabolic impairment, as reflected in NIRS by an increase in total Hb index (THI) and a decrease in the fractional tissue oxygenation extraction (FTOE); in HI+CBD the increase of THI was blunted and FTOE remained similar to SHAM. HI profoundly decreased EEG amplitude, which was not recovered in HI+vehicle, indicating cerebral hypofunction; seizures were observed in all HI+vehicle. In HI+CBD, however, EEG amplitude recovered to 46.4 7.8% baseline and seizures appeared only in 4/8 piglets (both p < 0.05). The number of viable neurons decreased and that of degenerating neurons increased in HI+vehicle; CBD reduced both effects by more than 50%. CBD administration was free from side effects; moreover, CBD administration was associated with cardiac, hemodynamic, and ventilatory beneficial effects. In conclusion, administration of CBD after HI reduced short-term brain damage and was associated with extracerebral benefits.

Authors+Show Affiliations

Laboratorio de Fisiopatología Perinatal Experimental, Gurutzetako Ospitalea, Bilbo, Bizkaia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18679164

Citation

Alvarez, Francisco J., et al. "Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-ischemic Newborn Piglets." Pediatric Research, vol. 64, no. 6, 2008, pp. 653-8.
Alvarez FJ, Lafuente H, Rey-Santano MC, et al. Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatr Res. 2008;64(6):653-8.
Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., ... Martínez-Orgado, J. (2008). Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatric Research, 64(6), pp. 653-8. doi:10.1203/PDR.0b013e318186e5dd.
Alvarez FJ, et al. Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-ischemic Newborn Piglets. Pediatr Res. 2008;64(6):653-8. PubMed PMID: 18679164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. AU - Alvarez,Francisco J, AU - Lafuente,Hector, AU - Rey-Santano,M Carmen, AU - Mielgo,Victoria E, AU - Gastiasoro,Elena, AU - Rueda,Miguel, AU - Pertwee,Roger G, AU - Castillo,Ana I, AU - Romero,Julián, AU - Martínez-Orgado,José, PY - 2008/8/6/pubmed PY - 2009/1/23/medline PY - 2008/8/6/entrez SP - 653 EP - 8 JF - Pediatric research JO - Pediatr. Res. VL - 64 IS - 6 N2 - To test the neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol (CBD), piglets received i.v. CBD or vehicle after hypoxia-ischemia (HI: temporary occlusion of both carotid arteries plus hypoxia). Nonhypoxic-ischemic sham-operated piglets remained as controls. Brain damage was studied by near-infrared spectroscopy (NIRS) and amplitude-integrated electroencephalography (aEEG) and by histologic assessment (Nissl and FluoroJadeB staining). In HI+vehicle, HI led to severe cerebral hemodynamic and metabolic impairment, as reflected in NIRS by an increase in total Hb index (THI) and a decrease in the fractional tissue oxygenation extraction (FTOE); in HI+CBD the increase of THI was blunted and FTOE remained similar to SHAM. HI profoundly decreased EEG amplitude, which was not recovered in HI+vehicle, indicating cerebral hypofunction; seizures were observed in all HI+vehicle. In HI+CBD, however, EEG amplitude recovered to 46.4 7.8% baseline and seizures appeared only in 4/8 piglets (both p < 0.05). The number of viable neurons decreased and that of degenerating neurons increased in HI+vehicle; CBD reduced both effects by more than 50%. CBD administration was free from side effects; moreover, CBD administration was associated with cardiac, hemodynamic, and ventilatory beneficial effects. In conclusion, administration of CBD after HI reduced short-term brain damage and was associated with extracerebral benefits. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/18679164/Neuroprotective_effects_of_the_nonpsychoactive_cannabinoid_cannabidiol_in_hypoxic_ischemic_newborn_piglets_ L2 - http://dx.doi.org/10.1203/PDR.0b013e318186e5dd DB - PRIME DP - Unbound Medicine ER -