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Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study).
Biol Trace Elem Res. 2008 Winter; 126(1-3):76-82.BT

Abstract

Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue.

Authors+Show Affiliations

Department of Food Chemistry and Nutrition, Collegium Medicum Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland. Pawel.Zagrodzki@ifj.edu.plNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18679588

Citation

Zagrodzki, Paweł, and Ryszard Ratajczak. "Selenium Supplementation in Autoimmune Thyroiditis Female Patient--effects On Thyroid and Ovarian Functions (case Study)." Biological Trace Element Research, vol. 126, no. 1-3, 2008, pp. 76-82.
Zagrodzki P, Ratajczak R. Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study). Biol Trace Elem Res. 2008;126(1-3):76-82.
Zagrodzki, P., & Ratajczak, R. (2008). Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study). Biological Trace Element Research, 126(1-3), 76-82. https://doi.org/10.1007/s12011-008-8188-6
Zagrodzki P, Ratajczak R. Selenium Supplementation in Autoimmune Thyroiditis Female Patient--effects On Thyroid and Ovarian Functions (case Study). Biol Trace Elem Res. 2008;126(1-3):76-82. PubMed PMID: 18679588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study). AU - Zagrodzki,Paweł, AU - Ratajczak,Ryszard, Y1 - 2008/08/06/ PY - 2008/02/28/received PY - 2008/06/23/accepted PY - 2008/8/6/pubmed PY - 2009/4/22/medline PY - 2008/8/6/entrez SP - 76 EP - 82 JF - Biological trace element research JO - Biol Trace Elem Res VL - 126 IS - 1-3 N2 - Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/18679588/Selenium_supplementation_in_autoimmune_thyroiditis_female_patient__effects_on_thyroid_and_ovarian_functions__case_study__ L2 - https://dx.doi.org/10.1007/s12011-008-8188-6 DB - PRIME DP - Unbound Medicine ER -