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Systematic literature review of role of noroviruses in sporadic gastroenteritis.
Emerg Infect Dis. 2008 Aug; 14(8):1224-31.EI

Abstract

We conducted a systematic review of studies that used reverse transcription-PCR to diagnose norovirus (NoV) infections in patients with mild or moderate (outpatient) and severe (hospitalized) diarrhea. NoVs accounted for 12%(95% confidence interval [CI] 10%-15%) of severe gastroenteritis cases among children <5 years of age and 12% (95% CI 9%-15%) of mild and moderate diarrhea cases among persons of all ages. Of 19 studies among children <5 years of age, 7 were in developing countries where pooled prevalence of severe NoV disease (12%) was comparable to that for industrialized countries (12%). We estimate that each year NoVs cause 64,000 episodes of diarrhea requiring hospitalization and 900,000 clinic visits among children in industrialized countries, and up to 200,000 deaths of children <5 years of age in developing countries. Future efforts should focus on developing targeted strategies, possibly even vaccines, for preventing NoV disease and better documenting their impact among children living in developing countries, where >95% of the deaths from diarrhea occur.

Authors+Show Affiliations

Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. aul3@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

18680645

Citation

Patel, Manish M., et al. "Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis." Emerging Infectious Diseases, vol. 14, no. 8, 2008, pp. 1224-31.
Patel MM, Widdowson MA, Glass RI, et al. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerging Infect Dis. 2008;14(8):1224-31.
Patel, M. M., Widdowson, M. A., Glass, R. I., Akazawa, K., Vinjé, J., & Parashar, U. D. (2008). Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerging Infectious Diseases, 14(8), 1224-31. https://doi.org/10.3201/eid1408.071114
Patel MM, et al. Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis. Emerging Infect Dis. 2008;14(8):1224-31. PubMed PMID: 18680645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic literature review of role of noroviruses in sporadic gastroenteritis. AU - Patel,Manish M, AU - Widdowson,Marc-Alain, AU - Glass,Roger I, AU - Akazawa,Kenichiro, AU - Vinjé,Jan, AU - Parashar,Umesh D, PY - 2008/8/6/pubmed PY - 2008/10/29/medline PY - 2008/8/6/entrez SP - 1224 EP - 31 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 14 IS - 8 N2 - We conducted a systematic review of studies that used reverse transcription-PCR to diagnose norovirus (NoV) infections in patients with mild or moderate (outpatient) and severe (hospitalized) diarrhea. NoVs accounted for 12%(95% confidence interval [CI] 10%-15%) of severe gastroenteritis cases among children <5 years of age and 12% (95% CI 9%-15%) of mild and moderate diarrhea cases among persons of all ages. Of 19 studies among children <5 years of age, 7 were in developing countries where pooled prevalence of severe NoV disease (12%) was comparable to that for industrialized countries (12%). We estimate that each year NoVs cause 64,000 episodes of diarrhea requiring hospitalization and 900,000 clinic visits among children in industrialized countries, and up to 200,000 deaths of children <5 years of age in developing countries. Future efforts should focus on developing targeted strategies, possibly even vaccines, for preventing NoV disease and better documenting their impact among children living in developing countries, where >95% of the deaths from diarrhea occur. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/18680645/full_citation L2 - https://dx.doi.org/10.3201/eid1408.071114 DB - PRIME DP - Unbound Medicine ER -