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Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity.
Food Chem Toxicol. 2008 Sep; 46(9):3178-81.FC

Abstract

Oxidative stress due to abnormal production of reactive oxygen species has been implicated in the nephrotoxicity induced by a commonly used anticancer antibiotic doxorubicin (DXN). The nephroprotective effect of aqueous ethanol extract of Zingiber officinale (200 and 400mg/kg, p.o) was evaluated against doxorubicin-induced (15mg/kg, i.p) acute renal damage in rat. Serum urea and creatinine levels were evaluated as the markers of renal failure. Renal antioxidant status such as activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and level of reduced glutathione (GSH) were determined. Level of lipid peroxidation as equivalents of malondialdehyde (MDA), and glutathione-S-transferase (GST) activity were determined in the kidneys. Serum urea and creatinine levels were reduced in the Z. officinale (200 and 400mg/kg, p.o) plus DXN treated groups. The renal antioxidant enzymes activities such as SOD, CAT GPx, levels of GSH and GST activity were restored and that of MDA declined significantly (p<0.001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST.

Authors+Show Affiliations

Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala 680 555, India. taajith@rediffmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18680783

Citation

Ajith, T A., et al. "Protective Effect of Zingiber Officinale Roscoe Against Anticancer Drug Doxorubicin-induced Acute Nephrotoxicity." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 9, 2008, pp. 3178-81.
Ajith TA, Aswathy MS, Hema U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food Chem Toxicol. 2008;46(9):3178-81.
Ajith, T. A., Aswathy, M. S., & Hema, U. (2008). Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(9), 3178-81. https://doi.org/10.1016/j.fct.2008.07.004
Ajith TA, Aswathy MS, Hema U. Protective Effect of Zingiber Officinale Roscoe Against Anticancer Drug Doxorubicin-induced Acute Nephrotoxicity. Food Chem Toxicol. 2008;46(9):3178-81. PubMed PMID: 18680783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. AU - Ajith,T A, AU - Aswathy,M S, AU - Hema,U, Y1 - 2008/07/17/ PY - 2008/04/10/received PY - 2008/06/21/revised PY - 2008/07/11/accepted PY - 2008/8/6/pubmed PY - 2008/11/7/medline PY - 2008/8/6/entrez SP - 3178 EP - 81 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 9 N2 - Oxidative stress due to abnormal production of reactive oxygen species has been implicated in the nephrotoxicity induced by a commonly used anticancer antibiotic doxorubicin (DXN). The nephroprotective effect of aqueous ethanol extract of Zingiber officinale (200 and 400mg/kg, p.o) was evaluated against doxorubicin-induced (15mg/kg, i.p) acute renal damage in rat. Serum urea and creatinine levels were evaluated as the markers of renal failure. Renal antioxidant status such as activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and level of reduced glutathione (GSH) were determined. Level of lipid peroxidation as equivalents of malondialdehyde (MDA), and glutathione-S-transferase (GST) activity were determined in the kidneys. Serum urea and creatinine levels were reduced in the Z. officinale (200 and 400mg/kg, p.o) plus DXN treated groups. The renal antioxidant enzymes activities such as SOD, CAT GPx, levels of GSH and GST activity were restored and that of MDA declined significantly (p<0.001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18680783/Protective_effect_of_Zingiber_officinale_roscoe_against_anticancer_drug_doxorubicin_induced_acute_nephrotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00397-9 DB - PRIME DP - Unbound Medicine ER -