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Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.
J Nat Prod. 2008 Aug; 71(8):1481-4.JN

Abstract

The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3-10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC 50 8.1-48.5 microM) and butyrylcholinesterase (IC 50 0.4-4.0 microM). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Devkota KP
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany. devkotakpd@yahoo.com
Lenta BN
No affiliation info available
Wansi JD
No affiliation info available
Choudhary MI
No affiliation info available
Kisangau DP
No affiliation info available
Naz Q
No affiliation info available
Samreen
No affiliation info available
Sewald N
No affiliation info available

MeSH

AlkaloidsAnti-Bacterial AgentsAntiprotozoal AgentsBuxaceaeCholinesterase InhibitorsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructurePregnanesSpectrometry, Mass, Electrospray Ionization

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18681480

Citation

Devkota, Krishna P., et al. "Bioactive 5alpha-pregnane-type Steroidal Alkaloids From Sarcococca Hookeriana." Journal of Natural Products, vol. 71, no. 8, 2008, pp. 1481-4.
Devkota KP, Lenta BN, Wansi JD, et al. Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. J Nat Prod. 2008;71(8):1481-4.
Devkota, K. P., Lenta, B. N., Wansi, J. D., Choudhary, M. I., Kisangau, D. P., Naz, Q., Samreen, ., & Sewald, N. (2008). Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. Journal of Natural Products, 71(8), 1481-4. https://doi.org/10.1021/np800305b
Devkota KP, et al. Bioactive 5alpha-pregnane-type Steroidal Alkaloids From Sarcococca Hookeriana. J Nat Prod. 2008;71(8):1481-4. PubMed PMID: 18681480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. AU - Devkota,Krishna P, AU - Lenta,Bruno N, AU - Wansi,Jean D, AU - Choudhary,Muhammad I, AU - Kisangau,Daniel P, AU - Naz,Qamar, AU - Samreen,, AU - Sewald,Norbert, Y1 - 2008/08/06/ PY - 2008/8/7/pubmed PY - 2008/12/17/medline PY - 2008/8/7/entrez SP - 1481 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 8 N2 - The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3-10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC 50 8.1-48.5 microM) and butyrylcholinesterase (IC 50 0.4-4.0 microM). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/18681480/Bioactive_5alpha_pregnane_type_steroidal_alkaloids_from_Sarcococca_hookeriana_ L2 - https://doi.org/10.1021/np800305b DB - PRIME DP - Unbound Medicine ER -