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Reversible splenial lesion syndrome (RESLES): what's in a name?
J Neuroimaging 2011; 21(2):e1-14JN

Abstract

BACKGROUND

The presence of transient lesions involving the splenium of the corpus callosum (SCC) has been described in patients with encephalitis or encephalopathy of varied etiology. We have termed it RESLES (reversible splenial lesion syndrome).

PURPOSE

To describe 3 additional patients (2 encephalitis, 1 hypoglycemia) and review the literature to define this syndrome, its etiology, presentation, prognosis, and possible pathophysiological mechanisms.

METHODS

Search of the MEDLINE database from 1966 through 2007. English language article titles and abstracts were screened and the appropriate articles reviewed. Additional articles cited by original references were also reviewed.

RESULTS

RESLES is caused by antiepileptic drug withdrawal, infection, high-altitude cerebral edema (HACE), or metabolic disorders (hypoglycemia and hypernatremia). Complete resolution after a variable lapse is the rule. Clinical presentation is nonspecific, without evidence of callosal disconnection syndromes. Neuroimaging shows a nonenhancing, round-shaped lesion centered in the SCC that disappears after a variable lapse. Diffusion studies reveal DW hypersignal with low ADC values, suggestive of cytotoxic edema. Only HACE-related cases and 1 patient with pregabalin withdrawal showed high ADC values, consistent with vasogenic edema.

CONCLUSION

RESLES is a distinct clinicoradiological syndrome of varied etiology and benign course except in those patients with an underlying severe disorder.

Authors+Show Affiliations

Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain. hospit05@sarenet.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

18681931

Citation

Garcia-Monco, Juan Carlos, et al. "Reversible Splenial Lesion Syndrome (RESLES): What's in a Name?" Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, vol. 21, no. 2, 2011, pp. e1-14.
Garcia-Monco JC, Cortina IE, Ferreira E, et al. Reversible splenial lesion syndrome (RESLES): what's in a name? J Neuroimaging. 2011;21(2):e1-14.
Garcia-Monco, J. C., Cortina, I. E., Ferreira, E., Martínez, A., Ruiz, L., Cabrera, A., & Beldarrain, M. G. (2011). Reversible splenial lesion syndrome (RESLES): what's in a name? Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 21(2), pp. e1-14. doi:10.1111/j.1552-6569.2008.00279.x.
Garcia-Monco JC, et al. Reversible Splenial Lesion Syndrome (RESLES): What's in a Name. J Neuroimaging. 2011;21(2):e1-14. PubMed PMID: 18681931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversible splenial lesion syndrome (RESLES): what's in a name? AU - Garcia-Monco,Juan Carlos, AU - Cortina,Ines Escalza, AU - Ferreira,Eva, AU - Martínez,Amaia, AU - Ruiz,Lara, AU - Cabrera,Alberto, AU - Beldarrain,Marian Gomez, PY - 2008/8/7/pubmed PY - 2011/7/27/medline PY - 2008/8/7/entrez SP - e1 EP - 14 JF - Journal of neuroimaging : official journal of the American Society of Neuroimaging JO - J Neuroimaging VL - 21 IS - 2 N2 - BACKGROUND: The presence of transient lesions involving the splenium of the corpus callosum (SCC) has been described in patients with encephalitis or encephalopathy of varied etiology. We have termed it RESLES (reversible splenial lesion syndrome). PURPOSE: To describe 3 additional patients (2 encephalitis, 1 hypoglycemia) and review the literature to define this syndrome, its etiology, presentation, prognosis, and possible pathophysiological mechanisms. METHODS: Search of the MEDLINE database from 1966 through 2007. English language article titles and abstracts were screened and the appropriate articles reviewed. Additional articles cited by original references were also reviewed. RESULTS: RESLES is caused by antiepileptic drug withdrawal, infection, high-altitude cerebral edema (HACE), or metabolic disorders (hypoglycemia and hypernatremia). Complete resolution after a variable lapse is the rule. Clinical presentation is nonspecific, without evidence of callosal disconnection syndromes. Neuroimaging shows a nonenhancing, round-shaped lesion centered in the SCC that disappears after a variable lapse. Diffusion studies reveal DW hypersignal with low ADC values, suggestive of cytotoxic edema. Only HACE-related cases and 1 patient with pregabalin withdrawal showed high ADC values, consistent with vasogenic edema. CONCLUSION: RESLES is a distinct clinicoradiological syndrome of varied etiology and benign course except in those patients with an underlying severe disorder. SN - 1552-6569 UR - https://www.unboundmedicine.com/medline/citation/18681931/Reversible_splenial_lesion_syndrome__RESLES_:_what's_in_a_name L2 - https://doi.org/10.1111/j.1552-6569.2008.00279.x DB - PRIME DP - Unbound Medicine ER -