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Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease.
J Hepatol. 2008 Oct; 49(4):608-12.JH

Abstract

BACKGROUND/AIMS

The natural history of non-alcoholic fatty liver disease (NAFLD) remains to be defined. We conducted a study to determine the overall and liver-related mortality of NAFLD in the general US population.

METHODS

In this study, the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES III-Linked Mortality File were used. Adjusted hazard ratios (HR) for overall and liver-related mortality were calculated for NAFLD using persons without liver disease as reference. Causes of death were determined.

RESULTS

After a median follow-up of 8.7 years, 80 persons with NAFLD and 1453 without liver disease died. Older age, male gender, non-Hispanic white race, lower educational level, lower income, higher BMI, presence of hypertension, diabetes mellitus, or metabolic syndrome were significantly (p<0.05) associated with overall mortality. Persons with NAFLD had higher overall mortality [HR 1.038 (95% CI 1.036-1.041), P<0.0001] and liver-related mortality [HR 9.32 (95% CI 9.21-9.43), P<0.0001]. Liver disease was the third leading cause of death among persons with NAFLD after cardiovascular disease and malignancy.

CONCLUSIONS

NAFLD is associated with higher overall and liver-related mortality in the general US population. Liver disease is a significant cause of death among persons with NAFLD.

Authors+Show Affiliations

Center for Liver Diseases, INOVA Fairfax Hospital, Annandale, VA 22003, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18682312

Citation

Ong, Janus P., et al. "Increased Overall Mortality and Liver-related Mortality in Non-alcoholic Fatty Liver Disease." Journal of Hepatology, vol. 49, no. 4, 2008, pp. 608-12.
Ong JP, Pitts A, Younossi ZM. Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol. 2008;49(4):608-12.
Ong, J. P., Pitts, A., & Younossi, Z. M. (2008). Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. Journal of Hepatology, 49(4), 608-12. https://doi.org/10.1016/j.jhep.2008.06.018
Ong JP, Pitts A, Younossi ZM. Increased Overall Mortality and Liver-related Mortality in Non-alcoholic Fatty Liver Disease. J Hepatol. 2008;49(4):608-12. PubMed PMID: 18682312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. AU - Ong,Janus P, AU - Pitts,Angela, AU - Younossi,Zobair M, Y1 - 2008/07/09/ PY - 2008/04/21/received PY - 2008/06/03/revised PY - 2008/06/10/accepted PY - 2008/8/7/pubmed PY - 2009/1/14/medline PY - 2008/8/7/entrez SP - 608 EP - 12 JF - Journal of hepatology JO - J Hepatol VL - 49 IS - 4 N2 - BACKGROUND/AIMS: The natural history of non-alcoholic fatty liver disease (NAFLD) remains to be defined. We conducted a study to determine the overall and liver-related mortality of NAFLD in the general US population. METHODS: In this study, the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES III-Linked Mortality File were used. Adjusted hazard ratios (HR) for overall and liver-related mortality were calculated for NAFLD using persons without liver disease as reference. Causes of death were determined. RESULTS: After a median follow-up of 8.7 years, 80 persons with NAFLD and 1453 without liver disease died. Older age, male gender, non-Hispanic white race, lower educational level, lower income, higher BMI, presence of hypertension, diabetes mellitus, or metabolic syndrome were significantly (p<0.05) associated with overall mortality. Persons with NAFLD had higher overall mortality [HR 1.038 (95% CI 1.036-1.041), P<0.0001] and liver-related mortality [HR 9.32 (95% CI 9.21-9.43), P<0.0001]. Liver disease was the third leading cause of death among persons with NAFLD after cardiovascular disease and malignancy. CONCLUSIONS: NAFLD is associated with higher overall and liver-related mortality in the general US population. Liver disease is a significant cause of death among persons with NAFLD. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/18682312/Increased_overall_mortality_and_liver_related_mortality_in_non_alcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(08)00423-6 DB - PRIME DP - Unbound Medicine ER -