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[Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study].
Zhonghua Fu Chan Ke Za Zhi. 2008 Feb; 43(2):98-101.ZF

Abstract

OBJECTIVE

To explore the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS).

METHODS

A case-control study employing 60 nonpregnant patients with PCOS and 60 non-pregnant patients without PCOS as control was conducted to compare the prevalence of NAFLD.

RESULTS

The aminotransferase (ALT), fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) levels were (29 +/- 15) U/L, (19 +/- 12) mU/L and 0.47 +/- 0.29 in PCOS group, which were significantly higher (P < 0.05) than corresponding parameters in control group [(15 +/- 13) U/L, (11 +/- 8) mU/L and 0.31 +/- 0.21)]. The occurrence of insulin resistance and NAFLD was63% (38/60) and 42% (25/60), higher than those in control group [35% (21/60) and 20% (12/60), P < 0.05]. The increment of ALT was 40% (24/60) in PCOS group, higher than that of 3% (2/60) in control group (P < 0.01). Compared with patients without NAFLD, patients with NAFLD had significantly increased body mass index (P < 0.01), waist-hip ratio, ALT, C-reaction protein, fasting insulin, insulin and HOMA-IR levels 2 hours after oral glucose tolerance test (P < 0. 05).

CONCLUSION

The increased prevalence of NAFLD in PCOS patients suggests an association between these two conditions and the necessity of hepatic screening among PCOS patients for potential NAFLD.

Authors+Show Affiliations

Department of Reproduction, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou 310003, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18683746

Citation

Zheng, Ruo-Heng, and Cai-Fei Ding. "[Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Polycystic Ovary Syndrome: a Case-control Study]." Zhonghua Fu Chan Ke Za Zhi, vol. 43, no. 2, 2008, pp. 98-101.
Zheng RH, Ding CF. [Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study]. Zhonghua Fu Chan Ke Za Zhi. 2008;43(2):98-101.
Zheng, R. H., & Ding, C. F. (2008). [Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study]. Zhonghua Fu Chan Ke Za Zhi, 43(2), 98-101.
Zheng RH, Ding CF. [Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Polycystic Ovary Syndrome: a Case-control Study]. Zhonghua Fu Chan Ke Za Zhi. 2008;43(2):98-101. PubMed PMID: 18683746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study]. AU - Zheng,Ruo-Heng, AU - Ding,Cai-Fei, PY - 2008/8/8/pubmed PY - 2011/10/1/medline PY - 2008/8/8/entrez SP - 98 EP - 101 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 43 IS - 2 N2 - OBJECTIVE: To explore the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). METHODS: A case-control study employing 60 nonpregnant patients with PCOS and 60 non-pregnant patients without PCOS as control was conducted to compare the prevalence of NAFLD. RESULTS: The aminotransferase (ALT), fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) levels were (29 +/- 15) U/L, (19 +/- 12) mU/L and 0.47 +/- 0.29 in PCOS group, which were significantly higher (P < 0.05) than corresponding parameters in control group [(15 +/- 13) U/L, (11 +/- 8) mU/L and 0.31 +/- 0.21)]. The occurrence of insulin resistance and NAFLD was63% (38/60) and 42% (25/60), higher than those in control group [35% (21/60) and 20% (12/60), P < 0.05]. The increment of ALT was 40% (24/60) in PCOS group, higher than that of 3% (2/60) in control group (P < 0.01). Compared with patients without NAFLD, patients with NAFLD had significantly increased body mass index (P < 0.01), waist-hip ratio, ALT, C-reaction protein, fasting insulin, insulin and HOMA-IR levels 2 hours after oral glucose tolerance test (P < 0. 05). CONCLUSION: The increased prevalence of NAFLD in PCOS patients suggests an association between these two conditions and the necessity of hepatic screening among PCOS patients for potential NAFLD. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/18683746/[Prevalence_of_nonalcoholic_fatty_liver_disease_in_patients_with_polycystic_ovary_syndrome:_a_case_control_study]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-567X&amp;year=2008&amp;vol=43&amp;issue=2&amp;fpage=98 DB - PRIME DP - Unbound Medicine ER -