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[Distribution and significance of IgG subclasses of serum antithyroglobulin antibody in Hashimoto thyroiditis].
Zhonghua Nei Ke Za Zhi 2008; 47(2):121-4ZN

Abstract

OBJECTIVE

To evaluate the distribution and significance of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis.

METHODS

Sera from 112 patients with Hashimoto thyroiditis were collected and patients were divided into 3 groups, i. e. hypothyroidism, subclinical hypothyroidism and euthyroidism. Antigen specific ELISA was used to detect the distribution of IgG subclasses of antithyroglobulin antibody.

RESULTS

The positive rates of IgG subclasses of TgAb were IgG1 90.2%, IgG2 58.0%, IgG3 19.6% and IgG4 87.5% respectively. The mean geometric titers of IgG1 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1: 450.8 and 1: 245.5 respectively, both being significantly higher than that with euthyroidism (1:8.7, P < 0.01). The mean geometric titers of IgG2 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1: 37.3 and 1: 3.2 respectively, both being also significantly higher than that with euthyroidism (1: 0.2, P < 0.01 and P < 0.05 respectively) and that with hypothyroidism was significantly higher than that with subclinical hypothyroidism (P < 0.05).

CONCLUSION

The distribution of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis was predominantly IgG1, IgG2 and IgG4. High titers of IgG1 and IgG2 implicated the possibility of development from subclinical hypothyroidism to overt hypothyroidism.

Authors+Show Affiliations

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18683798

Citation

Li, Mao-rong, et al. "[Distribution and Significance of IgG Subclasses of Serum Antithyroglobulin Antibody in Hashimoto Thyroiditis]." Zhonghua Nei Ke Za Zhi, vol. 47, no. 2, 2008, pp. 121-4.
Li MR, Guo XH, Gao Y, et al. [Distribution and significance of IgG subclasses of serum antithyroglobulin antibody in Hashimoto thyroiditis]. Zhonghua Nei Ke Za Zhi. 2008;47(2):121-4.
Li, M. R., Guo, X. H., Gao, Y., Gao, Y. M., Lu, G. Z., Hui, Y., ... Teng, W. P. (2008). [Distribution and significance of IgG subclasses of serum antithyroglobulin antibody in Hashimoto thyroiditis]. Zhonghua Nei Ke Za Zhi, 47(2), pp. 121-4.
Li MR, et al. [Distribution and Significance of IgG Subclasses of Serum Antithyroglobulin Antibody in Hashimoto Thyroiditis]. Zhonghua Nei Ke Za Zhi. 2008;47(2):121-4. PubMed PMID: 18683798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Distribution and significance of IgG subclasses of serum antithyroglobulin antibody in Hashimoto thyroiditis]. AU - Li,Mao-rong, AU - Guo,Xiao-hui, AU - Gao,Ying, AU - Gao,Yan-ming, AU - Lu,Gui-zhi, AU - Hui,Yan, AU - Wang,Shu-feng, AU - Shi,Bing-yin, AU - Teng,Wei-ping, PY - 2008/8/8/pubmed PY - 2009/3/4/medline PY - 2008/8/8/entrez SP - 121 EP - 4 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 47 IS - 2 N2 - OBJECTIVE: To evaluate the distribution and significance of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis. METHODS: Sera from 112 patients with Hashimoto thyroiditis were collected and patients were divided into 3 groups, i. e. hypothyroidism, subclinical hypothyroidism and euthyroidism. Antigen specific ELISA was used to detect the distribution of IgG subclasses of antithyroglobulin antibody. RESULTS: The positive rates of IgG subclasses of TgAb were IgG1 90.2%, IgG2 58.0%, IgG3 19.6% and IgG4 87.5% respectively. The mean geometric titers of IgG1 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1: 450.8 and 1: 245.5 respectively, both being significantly higher than that with euthyroidism (1:8.7, P < 0.01). The mean geometric titers of IgG2 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1: 37.3 and 1: 3.2 respectively, both being also significantly higher than that with euthyroidism (1: 0.2, P < 0.01 and P < 0.05 respectively) and that with hypothyroidism was significantly higher than that with subclinical hypothyroidism (P < 0.05). CONCLUSION: The distribution of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis was predominantly IgG1, IgG2 and IgG4. High titers of IgG1 and IgG2 implicated the possibility of development from subclinical hypothyroidism to overt hypothyroidism. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/18683798/[Distribution_and_significance_of_IgG_subclasses_of_serum_antithyroglobulin_antibody_in_Hashimoto_thyroiditis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0578-1426&amp;year=2008&amp;vol=47&amp;issue=2&amp;fpage=121 DB - PRIME DP - Unbound Medicine ER -