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Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning.
Hippocampus. 2009 Jan; 19(1):33-44.H

Abstract

Trace conditioning relies on the maintained representation of a stimulus across a trace interval, and may involve a persistent trace of the conditioned stimulus (CS) and/or a contribution of contextual conditioning. The role of hippocampal structures in these two types of conditioning was studied by means of pretraining lesions and reversible inactivation of the hippocampus in rats. Similar levels of conditioning to a tone CS and to the context were obtained with a trace interval of 30 s. Neurotoxic lesions of the whole hippocampus or reversible muscimol inactivation of the ventral hippocampus impaired both contextual and tone freezing in both trace- and delay-conditioned rats. Dorsal hippocampal injections impaired contextual freezing and trace conditioning, but not delay conditioning. No dissociation between trace and contextual conditioning was observed under any of these conditions. Altogether, these data indicate that the ventral and dorsal parts of the hippocampus compute different aspects of trace conditioning, with the ventral hippocampus being involved in fear and anxiety processes, and the dorsal hippocampus in the temporal and contextual aspects of event representation.

Authors+Show Affiliations

Université de Bordeaux, Centre de Neurosciences Intégratives et Cognitives, C.N.R.S. UMR 5228, Talence, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18683846

Citation

Esclassan, Frederic, et al. "Differential Contribution of Dorsal and Ventral Hippocampus to Trace and Delay Fear Conditioning." Hippocampus, vol. 19, no. 1, 2009, pp. 33-44.
Esclassan F, Coutureau E, Di Scala G, et al. Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. Hippocampus. 2009;19(1):33-44.
Esclassan, F., Coutureau, E., Di Scala, G., & Marchand, A. R. (2009). Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. Hippocampus, 19(1), 33-44. https://doi.org/10.1002/hipo.20473
Esclassan F, et al. Differential Contribution of Dorsal and Ventral Hippocampus to Trace and Delay Fear Conditioning. Hippocampus. 2009;19(1):33-44. PubMed PMID: 18683846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. AU - Esclassan,Frederic, AU - Coutureau,Etienne, AU - Di Scala,Georges, AU - Marchand,Alain R, PY - 2008/8/8/pubmed PY - 2009/2/28/medline PY - 2008/8/8/entrez SP - 33 EP - 44 JF - Hippocampus JO - Hippocampus VL - 19 IS - 1 N2 - Trace conditioning relies on the maintained representation of a stimulus across a trace interval, and may involve a persistent trace of the conditioned stimulus (CS) and/or a contribution of contextual conditioning. The role of hippocampal structures in these two types of conditioning was studied by means of pretraining lesions and reversible inactivation of the hippocampus in rats. Similar levels of conditioning to a tone CS and to the context were obtained with a trace interval of 30 s. Neurotoxic lesions of the whole hippocampus or reversible muscimol inactivation of the ventral hippocampus impaired both contextual and tone freezing in both trace- and delay-conditioned rats. Dorsal hippocampal injections impaired contextual freezing and trace conditioning, but not delay conditioning. No dissociation between trace and contextual conditioning was observed under any of these conditions. Altogether, these data indicate that the ventral and dorsal parts of the hippocampus compute different aspects of trace conditioning, with the ventral hippocampus being involved in fear and anxiety processes, and the dorsal hippocampus in the temporal and contextual aspects of event representation. SN - 1098-1063 UR - https://www.unboundmedicine.com/medline/citation/18683846/Differential_contribution_of_dorsal_and_ventral_hippocampus_to_trace_and_delay_fear_conditioning_ L2 - https://doi.org/10.1002/hipo.20473 DB - PRIME DP - Unbound Medicine ER -