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The current status of intestinal transplantation.
Curr Opin Organ Transplant. 2008 Jun; 13(3):266-72.CO

Abstract

PURPOSE OF REVIEW

The aim of this article is to assess the current status of intestinal transplantation.

RECENT FINDINGS

Long-term parenteral nutrition, while often life-sustaining, can be associated with life-threatening complications including parenteral nutrition-associated liver disease. Intestine transplant was developed to rescue patients that are at high risk of these complications. Most patients, however, are not considered for an intestinal transplant until they develop severe parenteral nutrition-associated liver disease and require a liver transplant also. Candidates referred this late have inferior outcomes both on the waiting list and after transplant compared with patients referred earlier needing only and intestine transplant. Rejection remains a difficult problem after intestinal transplantation, but infectious complications continue to be the major cause of morbidity and mortality. Outcomes with intestinal transplantation are steadily improving and 1-year patient survival for intestine only transplants is similar to liver transplants. Intestinal transplantation should be considered earlier in patients at high risk for developing parenteral nutrition-associated liver disease and other life-threatening complications. Better risk-stratification criteria are needed to identify these patients in a timely manner.

SUMMARY

The role of intestinal transplantation in the overall management of intestinal failure continues to evolve as its outcomes progressively improve and the risk factors for parenteral nutrition therapy failure become better defined.

Authors+Show Affiliations

Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. jfryer@nmh.org

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18685315

Citation

Fryer, Jonathan P.. "The Current Status of Intestinal Transplantation." Current Opinion in Organ Transplantation, vol. 13, no. 3, 2008, pp. 266-72.
Fryer JP. The current status of intestinal transplantation. Curr Opin Organ Transplant. 2008;13(3):266-72.
Fryer, J. P. (2008). The current status of intestinal transplantation. Current Opinion in Organ Transplantation, 13(3), 266-72. https://doi.org/10.1097/MOT.0b013e3282fd6901
Fryer JP. The Current Status of Intestinal Transplantation. Curr Opin Organ Transplant. 2008;13(3):266-72. PubMed PMID: 18685315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The current status of intestinal transplantation. A1 - Fryer,Jonathan P, PY - 2008/8/8/pubmed PY - 2008/10/29/medline PY - 2008/8/8/entrez SP - 266 EP - 72 JF - Current opinion in organ transplantation JO - Curr Opin Organ Transplant VL - 13 IS - 3 N2 - PURPOSE OF REVIEW: The aim of this article is to assess the current status of intestinal transplantation. RECENT FINDINGS: Long-term parenteral nutrition, while often life-sustaining, can be associated with life-threatening complications including parenteral nutrition-associated liver disease. Intestine transplant was developed to rescue patients that are at high risk of these complications. Most patients, however, are not considered for an intestinal transplant until they develop severe parenteral nutrition-associated liver disease and require a liver transplant also. Candidates referred this late have inferior outcomes both on the waiting list and after transplant compared with patients referred earlier needing only and intestine transplant. Rejection remains a difficult problem after intestinal transplantation, but infectious complications continue to be the major cause of morbidity and mortality. Outcomes with intestinal transplantation are steadily improving and 1-year patient survival for intestine only transplants is similar to liver transplants. Intestinal transplantation should be considered earlier in patients at high risk for developing parenteral nutrition-associated liver disease and other life-threatening complications. Better risk-stratification criteria are needed to identify these patients in a timely manner. SUMMARY: The role of intestinal transplantation in the overall management of intestinal failure continues to evolve as its outcomes progressively improve and the risk factors for parenteral nutrition therapy failure become better defined. SN - 1531-7013 UR - https://www.unboundmedicine.com/medline/citation/18685315/The_current_status_of_intestinal_transplantation_ L2 - https://doi.org/10.1097/MOT.0b013e3282fd6901 DB - PRIME DP - Unbound Medicine ER -