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Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.
Eur J Clin Nutr. 2009 Jun; 63(6):707-17.EJ

Abstract

BACKGROUND/OBJECTIVES

To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.

SUBJECTS/METHODS

A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293,576) and women (n=198,730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.

RESULTS

In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.

CONCLUSIONS

These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.

Authors+Show Affiliations

Nutrition Epidemiology, Department of Clinical Sciences (Malmö), Lund University, Malmö, Sweden. elisabet.wirfalt@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18685556

Citation

Wirfält, E, et al. "Associations Between Food Patterns Defined By Cluster Analysis and Colorectal Cancer Incidence in the NIH-AARP Diet and Health Study." European Journal of Clinical Nutrition, vol. 63, no. 6, 2009, pp. 707-17.
Wirfält E, Midthune D, Reedy J, et al. Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study. Eur J Clin Nutr. 2009;63(6):707-17.
Wirfält, E., Midthune, D., Reedy, J., Mitrou, P., Flood, A., Subar, A. F., Leitzmann, M., Mouw, T., Hollenbeck, A. R., Schatzkin, A., & Kipnis, V. (2009). Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study. European Journal of Clinical Nutrition, 63(6), 707-17. https://doi.org/10.1038/ejcn.2008.40
Wirfält E, et al. Associations Between Food Patterns Defined By Cluster Analysis and Colorectal Cancer Incidence in the NIH-AARP Diet and Health Study. Eur J Clin Nutr. 2009;63(6):707-17. PubMed PMID: 18685556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study. AU - Wirfält,E, AU - Midthune,D, AU - Reedy,J, AU - Mitrou,P, AU - Flood,A, AU - Subar,A F, AU - Leitzmann,M, AU - Mouw,T, AU - Hollenbeck,A R, AU - Schatzkin,A, AU - Kipnis,V, Y1 - 2008/08/06/ PY - 2008/8/8/pubmed PY - 2009/9/2/medline PY - 2008/8/8/entrez SP - 707 EP - 17 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 6 N2 - BACKGROUND/OBJECTIVES: To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study. SUBJECTS/METHODS: A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293,576) and women (n=198,730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence. RESULTS: In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis. CONCLUSIONS: These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/18685556/Associations_between_food_patterns_defined_by_cluster_analysis_and_colorectal_cancer_incidence_in_the_NIH_AARP_diet_and_health_study_ L2 - https://doi.org/10.1038/ejcn.2008.40 DB - PRIME DP - Unbound Medicine ER -