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Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions.
Drug Deliv. 2008 Aug; 15(6):355-64.DD

Abstract

To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). They were evaluated for solubility, in vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and resolidification as revealed by SEM indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. However, no such interactions in the solid state were confirmed by FTIR spectra that showed the presence of drug crystalline in SDs. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast-dissolving ibuprofen SDs by low temperature melting method using PEG 6000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18686079

Citation

Newa, Madhuri, et al. "Preparation and Evaluation of Fast Dissolving Ibuprofen-polyethylene Glycol 6000 Solid Dispersions." Drug Delivery, vol. 15, no. 6, 2008, pp. 355-64.
Newa M, Bhandari KH, Kim JA, et al. Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions. Drug Deliv. 2008;15(6):355-64.
Newa, M., Bhandari, K. H., Kim, J. A., Yoo, B. K., Choi, H. G., Yong, C. S., Woo, J. S., & Lyoo, W. S. (2008). Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions. Drug Delivery, 15(6), 355-64. https://doi.org/10.1080/10717540801952431
Newa M, et al. Preparation and Evaluation of Fast Dissolving Ibuprofen-polyethylene Glycol 6000 Solid Dispersions. Drug Deliv. 2008;15(6):355-64. PubMed PMID: 18686079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions. AU - Newa,Madhuri, AU - Bhandari,Krishna H, AU - Kim,Jung-Ae, AU - Yoo,Bong-Kyu, AU - Choi,Han-Gon, AU - Yong,Chul-Soon, AU - Woo,Jong-Soo, AU - Lyoo,Won-Seok, PY - 2008/8/8/pubmed PY - 2008/9/10/medline PY - 2008/8/8/entrez SP - 355 EP - 64 JF - Drug delivery JO - Drug Deliv VL - 15 IS - 6 N2 - To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). They were evaluated for solubility, in vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and resolidification as revealed by SEM indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. However, no such interactions in the solid state were confirmed by FTIR spectra that showed the presence of drug crystalline in SDs. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast-dissolving ibuprofen SDs by low temperature melting method using PEG 6000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/18686079/Preparation_and_evaluation_of_fast_dissolving_ibuprofen_polyethylene_glycol_6000_solid_dispersions_ L2 - https://www.tandfonline.com/doi/full/10.1080/10717540801952431 DB - PRIME DP - Unbound Medicine ER -