Tags

Type your tag names separated by a space and hit enter

Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000.
Drug Dev Ind Pharm. 2008 Oct; 34(10):1013-21.DD

Abstract

To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast dissolving ibuprofen SDs by low-temperature melting method using polyethylene glycol 20000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18686087

Citation

Newa, Madhuri, et al. "Enhanced Dissolution of Ibuprofen Using Solid Dispersion With Polyethylene Glycol 20000." Drug Development and Industrial Pharmacy, vol. 34, no. 10, 2008, pp. 1013-21.
Newa M, Bhandari KH, Lee DX, et al. Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000. Drug Dev Ind Pharm. 2008;34(10):1013-21.
Newa, M., Bhandari, K. H., Lee, D. X., Sung, J. H., Kim, J. A., Yoo, B. K., Woo, J. S., Choi, H. G., & Yong, C. S. (2008). Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000. Drug Development and Industrial Pharmacy, 34(10), 1013-21. https://doi.org/10.1080/03639040701744095
Newa M, et al. Enhanced Dissolution of Ibuprofen Using Solid Dispersion With Polyethylene Glycol 20000. Drug Dev Ind Pharm. 2008;34(10):1013-21. PubMed PMID: 18686087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000. AU - Newa,Madhuri, AU - Bhandari,Krishna Hari, AU - Lee,Dong Xun, AU - Sung,Jung Hoon, AU - Kim,Jung Ae, AU - Yoo,Bong Kyu, AU - Woo,Jong Soo, AU - Choi,Han Gon, AU - Yong,Chul Soon, PY - 2008/8/8/pubmed PY - 2008/11/19/medline PY - 2008/8/8/entrez SP - 1013 EP - 21 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 34 IS - 10 N2 - To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast dissolving ibuprofen SDs by low-temperature melting method using polyethylene glycol 20000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/18686087/Enhanced_dissolution_of_ibuprofen_using_solid_dispersion_with_polyethylene_glycol_20000_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040701744095 DB - PRIME DP - Unbound Medicine ER -