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The influence of various amphiphilic excipients on the physicochemical properties of carbamazepine-loaded microparticles.
J Microencapsul. 2009 May; 26(3):251-62.JM

Abstract

The objective of the present study was to prepare multiple-unit formulations of carbamazepine (CBZ) using an emulsion congealing technique. CBZ-hydrogenated castor oil (HCO) (Cutina® HR) wax microparticles were prepared without organic solvents as an alternative to polymeric microparticles. The process involved emulsification and solidification of CBZ-HCO melt at a significantly low temperature (5°C). Five amphiphilic excipients (Pluronic F-68 (PL), Labrasol (LB), Gelucire 44/14 (GL 44/14), D-α-tocopheryl PEG 1000 succinate (TPGS) and Docusate sodium (DOSS) were added with the wax melt. The microparticles were characterized with respect to their particle size distribution, drug loading, morphological character, drug-excipient interaction, differential scanning calorimetry, Fourier-transform infra-red (FT-IR) and release properties. An average value for production yield was 83.45%. Evaluation of the release data indicates that the release mechanism from the prepared Cutina® HR microparticles follows both the Higuchi model of diffusion and anomalous release mechanism. Microparticles containing 5% Labrasol, TPGS and GL 44/14 had the highest extent of dissolution.

Authors+Show Affiliations

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. nsybarakat@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18686144

Citation

Barakat, Nahla S., et al. "The Influence of Various Amphiphilic Excipients On the Physicochemical Properties of Carbamazepine-loaded Microparticles." Journal of Microencapsulation, vol. 26, no. 3, 2009, pp. 251-62.
Barakat NS, Elanazi FK, Almurshedi AS. The influence of various amphiphilic excipients on the physicochemical properties of carbamazepine-loaded microparticles. J Microencapsul. 2009;26(3):251-62.
Barakat, N. S., Elanazi, F. K., & Almurshedi, A. S. (2009). The influence of various amphiphilic excipients on the physicochemical properties of carbamazepine-loaded microparticles. Journal of Microencapsulation, 26(3), 251-62. https://doi.org/10.1080/02652040802305113
Barakat NS, Elanazi FK, Almurshedi AS. The Influence of Various Amphiphilic Excipients On the Physicochemical Properties of Carbamazepine-loaded Microparticles. J Microencapsul. 2009;26(3):251-62. PubMed PMID: 18686144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of various amphiphilic excipients on the physicochemical properties of carbamazepine-loaded microparticles. AU - Barakat,Nahla S, AU - Elanazi,Fars K, AU - Almurshedi,Alanood S, Y1 - 2008/10/20/ PY - 2008/8/8/pubmed PY - 2011/5/25/medline PY - 2008/8/8/entrez SP - 251 EP - 62 JF - Journal of microencapsulation JO - J Microencapsul VL - 26 IS - 3 N2 - The objective of the present study was to prepare multiple-unit formulations of carbamazepine (CBZ) using an emulsion congealing technique. CBZ-hydrogenated castor oil (HCO) (Cutina® HR) wax microparticles were prepared without organic solvents as an alternative to polymeric microparticles. The process involved emulsification and solidification of CBZ-HCO melt at a significantly low temperature (5°C). Five amphiphilic excipients (Pluronic F-68 (PL), Labrasol (LB), Gelucire 44/14 (GL 44/14), D-α-tocopheryl PEG 1000 succinate (TPGS) and Docusate sodium (DOSS) were added with the wax melt. The microparticles were characterized with respect to their particle size distribution, drug loading, morphological character, drug-excipient interaction, differential scanning calorimetry, Fourier-transform infra-red (FT-IR) and release properties. An average value for production yield was 83.45%. Evaluation of the release data indicates that the release mechanism from the prepared Cutina® HR microparticles follows both the Higuchi model of diffusion and anomalous release mechanism. Microparticles containing 5% Labrasol, TPGS and GL 44/14 had the highest extent of dissolution. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/18686144/The_influence_of_various_amphiphilic_excipients_on_the_physicochemical_properties_of_carbamazepine_loaded_microparticles_ L2 - https://www.tandfonline.com/doi/full/10.1080/02652040802305113 DB - PRIME DP - Unbound Medicine ER -