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On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health.
Mol Nutr Food Res 2008; 52(11):1235-46MN

Abstract

The trace elements iodine and selenium (Se) are essential for thyroid gland functioning and thyroid hormone biosynthesis and metabolism. While iodine is needed as the eponymous constituent of the two major thyroid hormones triiodo-L-thyronine (T3), and tetraiodo-L-thyronine (T4), Se is essential for the biosynthesis and function of a small number of selenocysteine (Sec)-containing selenoproteins implicated in thyroid hormone metabolism and gland function. The Se-dependent iodothyronine deiodinases control thyroid hormone turnover, while both intracellular and secreted Se-dependent glutathione peroxidases are implicated in gland protection. Recently, a number of clinical supplementation trials have indicated positive effects of increasing the Se status of the participants in a variety of pathologies. These findings enforce the notion that many people might profit from improving their Se status, both as a means to reduce the individual health risk as well as to balance a Se deficiency which often develops during the course of illness. Even though the underlying mechanisms are still largely uncharacterised, the effects of Se appear to be exerted via multiple different mechanisms that impact most pronounced on the endocrine and the immune systems.

Authors+Show Affiliations

Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungs-Centrum der Charité EnForCé, Charité Campus Virchow-Klinikum, Charité Universitätsmedizin, Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18686295

Citation

Schomburg, Lutz, and Josef Köhrle. "On the Importance of Selenium and Iodine Metabolism for Thyroid Hormone Biosynthesis and Human Health." Molecular Nutrition & Food Research, vol. 52, no. 11, 2008, pp. 1235-46.
Schomburg L, Köhrle J. On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. Mol Nutr Food Res. 2008;52(11):1235-46.
Schomburg, L., & Köhrle, J. (2008). On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. Molecular Nutrition & Food Research, 52(11), pp. 1235-46. doi:10.1002/mnfr.200700465.
Schomburg L, Köhrle J. On the Importance of Selenium and Iodine Metabolism for Thyroid Hormone Biosynthesis and Human Health. Mol Nutr Food Res. 2008;52(11):1235-46. PubMed PMID: 18686295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. AU - Schomburg,Lutz, AU - Köhrle,Josef, PY - 2008/8/8/pubmed PY - 2009/2/14/medline PY - 2008/8/8/entrez SP - 1235 EP - 46 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 52 IS - 11 N2 - The trace elements iodine and selenium (Se) are essential for thyroid gland functioning and thyroid hormone biosynthesis and metabolism. While iodine is needed as the eponymous constituent of the two major thyroid hormones triiodo-L-thyronine (T3), and tetraiodo-L-thyronine (T4), Se is essential for the biosynthesis and function of a small number of selenocysteine (Sec)-containing selenoproteins implicated in thyroid hormone metabolism and gland function. The Se-dependent iodothyronine deiodinases control thyroid hormone turnover, while both intracellular and secreted Se-dependent glutathione peroxidases are implicated in gland protection. Recently, a number of clinical supplementation trials have indicated positive effects of increasing the Se status of the participants in a variety of pathologies. These findings enforce the notion that many people might profit from improving their Se status, both as a means to reduce the individual health risk as well as to balance a Se deficiency which often develops during the course of illness. Even though the underlying mechanisms are still largely uncharacterised, the effects of Se appear to be exerted via multiple different mechanisms that impact most pronounced on the endocrine and the immune systems. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/18686295/On_the_importance_of_selenium_and_iodine_metabolism_for_thyroid_hormone_biosynthesis_and_human_health_ L2 - https://doi.org/10.1002/mnfr.200700465 DB - PRIME DP - Unbound Medicine ER -