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[Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD].

Abstract

AIM

To evaluate the association of PTPN22 gene polymorphism with autoimmune thyroid disease (AITD) in Chinese people and to analyze the relationship between SNP of CTLA-4 gene and SNP of PTPN22 gene.

METHODS

149 patients with Graves' disease (GD) and 82 patients with Hashimoto's thyroiditis (HT) as well as 131 healthy people as controls were investigated. PTPN22 gene polymorphism +1858 C>T and CTLA-4 gene polymorphism 49A>G were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). PTPN22 gene polymorphism -1123G>C at promoter was genotyped by single allele-specific primer polymerase chain reaction (SASP-PCR).

RESULTS

(1) +1858C>T for PTPN22 gene was not polymorphic enough in patients and controls. (2) Statistic differences in alleles and genotype frequency of -1123G>C were observed between GD patients and controls (P=0.040, 0.013; OR=1.44, 2.33, respectively). (3) Differences in alleles and genotype frequency of 49A>G for CTLA-4 gene were observed in patients and controls. (4) Individuals with PTPN22 CC genotype and CTILA-4 G alleles had an increased risk of developing GD (OR=3.31, 95%CI: 2.69-8.89) compared with those with PTPN22 G alleles and CTLA-4 AA genotype.

CONCLUSION

-1123 G>C SNP of PTPN22 gene is associated with GD. There is coordination between PTPN22 CC genotype and CTLA-4 G alleles in the development of GD.

Authors+Show Affiliations

Department of Endocrinology, First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, China. yuzhyun@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18687223

Citation

Yu, Zhi-Yun, et al. "[Association of Polymorphism of Protein Tyrosine Phosphatase Nonreceptor-22 Gene With AITD]." Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, vol. 24, no. 8, 2008, pp. 804-7.
Yu ZY, Zhang JA, Maier HB, et al. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24(8):804-7.
Yu, Z. Y., Zhang, J. A., Maier, H. B., Wang, Y., Xiao, W. X., Quan, Y., & Dong, B. N. (2008). [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, 24(8), pp. 804-7.
Yu ZY, et al. [Association of Polymorphism of Protein Tyrosine Phosphatase Nonreceptor-22 Gene With AITD]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24(8):804-7. PubMed PMID: 18687223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. AU - Yu,Zhi-Yun, AU - Zhang,Jin-An, AU - Maier,Ha-Ba, AU - Wang,Yu, AU - Xiao,Wan-Xia, AU - Quan,Ying, AU - Dong,Bao-Ning, PY - 2008/8/9/pubmed PY - 2010/4/3/medline PY - 2008/8/9/entrez SP - 804 EP - 7 JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology JO - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi VL - 24 IS - 8 N2 - AIM: To evaluate the association of PTPN22 gene polymorphism with autoimmune thyroid disease (AITD) in Chinese people and to analyze the relationship between SNP of CTLA-4 gene and SNP of PTPN22 gene. METHODS: 149 patients with Graves' disease (GD) and 82 patients with Hashimoto's thyroiditis (HT) as well as 131 healthy people as controls were investigated. PTPN22 gene polymorphism +1858 C>T and CTLA-4 gene polymorphism 49A>G were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). PTPN22 gene polymorphism -1123G>C at promoter was genotyped by single allele-specific primer polymerase chain reaction (SASP-PCR). RESULTS: (1) +1858C>T for PTPN22 gene was not polymorphic enough in patients and controls. (2) Statistic differences in alleles and genotype frequency of -1123G>C were observed between GD patients and controls (P=0.040, 0.013; OR=1.44, 2.33, respectively). (3) Differences in alleles and genotype frequency of 49A>G for CTLA-4 gene were observed in patients and controls. (4) Individuals with PTPN22 CC genotype and CTILA-4 G alleles had an increased risk of developing GD (OR=3.31, 95%CI: 2.69-8.89) compared with those with PTPN22 G alleles and CTLA-4 AA genotype. CONCLUSION: -1123 G>C SNP of PTPN22 gene is associated with GD. There is coordination between PTPN22 CC genotype and CTLA-4 G alleles in the development of GD. SN - 1007-8738 UR - https://www.unboundmedicine.com/medline/citation/18687223/[Association_of_polymorphism_of_protein_tyrosine_phosphatase_nonreceptor_22_gene_with_AITD]_ DB - PRIME DP - Unbound Medicine ER -