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The contribution of genes to osteoarthritis.
Rheum Dis Clin North Am. 2008 Aug; 34(3):581-603.RD

Abstract

Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of evidence, including familial aggregation and classic twin studies, indicates that primary OA has a strong hereditary component that is likely polygenic in nature. Furthermore, traits related to OA, such as longitudinal changes in cartilage volume and progression of radiographic features, are also under genetic control. In recent years, several linkage analysis and candidate gene studies have been performed and have unveiled some of the specific genes involved in disease risk, such as FRZB and GDF5. The authors discuss the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA.

Links

Aggregator Full Text
Publisher Full Text
linkinghub.elsevier.com
journals.elsevierhealth.com

Authors+Show Affiliations

Valdes AM
Twin Research & Genetic Epidemiology Unit, St. Thomas' Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK. ana.valdes@kcl.ac.uk
Spector TD
No affiliation info available

MeSH

Age FactorsAgedAged, 80 and overBone Morphogenetic ProteinsExtracellular Matrix ProteinsFemaleGene Expression RegulationGenetic LinkageGenetic Predisposition to DiseaseHumansMaleMiddle AgedOsteoarthritisOsteoarthritis, HipOsteoarthritis, KneePedigreeRisk AssessmentSensitivity and SpecificitySex Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18687274

Citation

Valdes, Ana M., and Timothy D. Spector. "The Contribution of Genes to Osteoarthritis." Rheumatic Diseases Clinics of North America, vol. 34, no. 3, 2008, pp. 581-603.
Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Rheum Dis Clin North Am. 2008;34(3):581-603.
Valdes, A. M., & Spector, T. D. (2008). The contribution of genes to osteoarthritis. Rheumatic Diseases Clinics of North America, 34(3), 581-603. https://doi.org/10.1016/j.rdc.2008.04.008
Valdes AM, Spector TD. The Contribution of Genes to Osteoarthritis. Rheum Dis Clin North Am. 2008;34(3):581-603. PubMed PMID: 18687274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contribution of genes to osteoarthritis. AU - Valdes,Ana M, AU - Spector,Timothy D, PY - 2008/8/9/pubmed PY - 2008/10/22/medline PY - 2008/8/9/entrez SP - 581 EP - 603 JF - Rheumatic diseases clinics of North America JO - Rheum Dis Clin North Am VL - 34 IS - 3 N2 - Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of evidence, including familial aggregation and classic twin studies, indicates that primary OA has a strong hereditary component that is likely polygenic in nature. Furthermore, traits related to OA, such as longitudinal changes in cartilage volume and progression of radiographic features, are also under genetic control. In recent years, several linkage analysis and candidate gene studies have been performed and have unveiled some of the specific genes involved in disease risk, such as FRZB and GDF5. The authors discuss the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA. SN - 1558-3163 UR - https://www.unboundmedicine.com/medline/citation/18687274/The_contribution_of_genes_to_osteoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-857X(08)00033-1 DB - PRIME DP - Unbound Medicine ER -