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Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat.
Brain Res. 2008 Sep 26; 1232:132-8.BR

Abstract

The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the possible role of hippocampal angiotensin II receptors in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the hippocampal angiotension II receptors, the animals received a single injection of latex microbeads for delivery of [Sar1 Thr8]-Angiotensin II into the hippocampus. The animals were exposed to five consecutive nights of exercise and then their learning and memory were tested on the Morris water maze (MWM) task using a two-trial-per-day for five consecutive days. A probe trial was performed 2 days after the last training day. Our results showed that hippocampal angiotensin II receptor blockade reversed the exercise-induced improvement in learning and memory in rat.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Semnan University of Medical Sciences, Damghan road, Faculty of Medicine, Semnan, 35198-99951 Iran. akmaziar@sem-ums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18687315

Citation

Akhavan, Maziar M., et al. "Hippocampal Angiotensin II Receptors Play an Important Role in Mediating the Effect of Voluntary Exercise On Learning and Memory in Rat." Brain Research, vol. 1232, 2008, pp. 132-8.
Akhavan MM, Emami-Abarghoie M, Sadighi-Moghaddam B, et al. Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat. Brain Res. 2008;1232:132-8.
Akhavan, M. M., Emami-Abarghoie, M., Sadighi-Moghaddam, B., Safari, M., Yousefi, Y., & Rashidy-Pour, A. (2008). Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat. Brain Research, 1232, 132-8. https://doi.org/10.1016/j.brainres.2008.07.042
Akhavan MM, et al. Hippocampal Angiotensin II Receptors Play an Important Role in Mediating the Effect of Voluntary Exercise On Learning and Memory in Rat. Brain Res. 2008 Sep 26;1232:132-8. PubMed PMID: 18687315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat. AU - Akhavan,Maziar M, AU - Emami-Abarghoie,Mitra, AU - Sadighi-Moghaddam,Bizhan, AU - Safari,Manouchehr, AU - Yousefi,Yasaman, AU - Rashidy-Pour,Ali, Y1 - 2008/07/19/ PY - 2008/01/15/received PY - 2008/07/08/revised PY - 2008/07/09/accepted PY - 2008/8/9/pubmed PY - 2008/12/17/medline PY - 2008/8/9/entrez SP - 132 EP - 8 JF - Brain research JO - Brain Res VL - 1232 N2 - The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the possible role of hippocampal angiotensin II receptors in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the hippocampal angiotension II receptors, the animals received a single injection of latex microbeads for delivery of [Sar1 Thr8]-Angiotensin II into the hippocampus. The animals were exposed to five consecutive nights of exercise and then their learning and memory were tested on the Morris water maze (MWM) task using a two-trial-per-day for five consecutive days. A probe trial was performed 2 days after the last training day. Our results showed that hippocampal angiotensin II receptor blockade reversed the exercise-induced improvement in learning and memory in rat. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/18687315/Hippocampal_angiotensin_II_receptors_play_an_important_role_in_mediating_the_effect_of_voluntary_exercise_on_learning_and_memory_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(08)01721-6 DB - PRIME DP - Unbound Medicine ER -