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Oral contraceptives and breast cancer: review of the epidemiologic literature.

Abstract

Oral contraceptives have caused little or no overall increase in risk of breast cancer in women in developed countries, even in long-term users or after more than two decades since initial exposure. Limited evidence suggests a possible small increase in risk in users of oral contraceptives in developing countries, and further studies of breast cancer and oral contraceptives in low risk populations are warranted. Oral contraceptives may enhance risk of breast cancer in young women with a history of benign breast disease, and this possibility should also be investigated further. Multiple investigations have fairly consistently shown risk of breast cancer in women under age 45 years to be increased slightly in long-term users of oral contraceptives. Further studies should be conducted to elucidate the mechanism of this apparent phenomenon.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

    Source

    Contraception 43:6 1991 Jun pg 597-642

    MeSH

    Breast Neoplasms
    Case-Control Studies
    Contraceptives, Oral
    Developing Countries
    Female
    Humans
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    1868735

    Citation

    Thomas, D B.. "Oral Contraceptives and Breast Cancer: Review of the Epidemiologic Literature." Contraception, vol. 43, no. 6, 1991, pp. 597-642.
    Thomas DB. Oral contraceptives and breast cancer: review of the epidemiologic literature. Contraception. 1991;43(6):597-642.
    Thomas, D. B. (1991). Oral contraceptives and breast cancer: review of the epidemiologic literature. Contraception, 43(6), pp. 597-642.
    Thomas DB. Oral Contraceptives and Breast Cancer: Review of the Epidemiologic Literature. Contraception. 1991;43(6):597-642. PubMed PMID: 1868735.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oral contraceptives and breast cancer: review of the epidemiologic literature. A1 - Thomas,D B, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez KW - Age Factors KW - Bias KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Cohort Analysis KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Critique KW - Data Aggregation KW - Demographic Factors KW - Developed Countries KW - Developing Countries KW - Diseases KW - Error Sources KW - Evaluation KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Literature Review KW - Measurement KW - Medroxyprogesterone Acetate KW - Menopause KW - Neoplasms KW - Neoplasms, Benign KW - Nulliparity KW - Oral Contraceptives KW - Parity KW - Population KW - Population At Risk KW - Population Characteristics KW - Population Dynamics KW - Reproduction KW - Research Methodology KW - Risk Assessment KW - Sampling Errors KW - Studies SP - 597 EP - 642 JF - Contraception JO - Contraception VL - 43 IS - 6 N2 - Oral contraceptives have caused little or no overall increase in risk of breast cancer in women in developed countries, even in long-term users or after more than two decades since initial exposure. Limited evidence suggests a possible small increase in risk in users of oral contraceptives in developing countries, and further studies of breast cancer and oral contraceptives in low risk populations are warranted. Oral contraceptives may enhance risk of breast cancer in young women with a history of benign breast disease, and this possibility should also be investigated further. Multiple investigations have fairly consistently shown risk of breast cancer in women under age 45 years to be increased slightly in long-term users of oral contraceptives. Further studies should be conducted to elucidate the mechanism of this apparent phenomenon. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/1868735/Oral_contraceptives_and_breast_cancer:_review_of_the_epidemiologic_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(91)90006-2 DB - PRIME DP - Unbound Medicine ER -