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Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population.
Fertil Steril. 2009 Jul; 92(1):54-60.FS

Abstract

OBJECTIVE

To determine whether polymorphisms of the estrogen receptor alpha (ERalpha) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population.

DESIGN

Association study.

SETTING

University hospital.

PATIENT(S)

Chinese women diagnosed with endometriosis by laparotomy or laparoscopy.

INTERVENTION(S)

Determination of polymorphisms of the ERalpha and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls.

MAIN OUTCOME MEASURE(S)

Frequency and distribution of PvuII and XbaI polymorphisms of ERalpha and of BslI, SspI, and RsaI polymorphisms of IL-10.

RESULT(S)

There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERalpha-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERalpha-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERalpha-XbaI was associated with endometriosis.

CONCLUSION(S)

The X allele of ERalpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.

Authors+Show Affiliations

Central Laboratory of Nanjing First Hospital affiliated to Nanjing Medical University, Nanjing, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18687423

Citation

Xie, Jingyan, et al. "Association of Estrogen Receptor Alpha and Interleukin-10 Gene Polymorphisms With Endometriosis in a Chinese Population." Fertility and Sterility, vol. 92, no. 1, 2009, pp. 54-60.
Xie J, Wang S, He B, et al. Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population. Fertil Steril. 2009;92(1):54-60.
Xie, J., Wang, S., He, B., Pan, Y., Li, Y., Zeng, Q., Jiang, H., & Chen, J. (2009). Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population. Fertility and Sterility, 92(1), 54-60. https://doi.org/10.1016/j.fertnstert.2008.04.069
Xie J, et al. Association of Estrogen Receptor Alpha and Interleukin-10 Gene Polymorphisms With Endometriosis in a Chinese Population. Fertil Steril. 2009;92(1):54-60. PubMed PMID: 18687423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population. AU - Xie,Jingyan, AU - Wang,Shukui, AU - He,Bangshun, AU - Pan,Yuqin, AU - Li,Yujuan, AU - Zeng,Qingdi, AU - Jiang,Huaxin, AU - Chen,Jialiang, Y1 - 2008/08/08/ PY - 2008/03/26/received PY - 2008/04/30/revised PY - 2008/04/30/accepted PY - 2008/8/9/pubmed PY - 2009/7/30/medline PY - 2008/8/9/entrez SP - 54 EP - 60 JF - Fertility and sterility JO - Fertil Steril VL - 92 IS - 1 N2 - OBJECTIVE: To determine whether polymorphisms of the estrogen receptor alpha (ERalpha) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population. DESIGN: Association study. SETTING: University hospital. PATIENT(S): Chinese women diagnosed with endometriosis by laparotomy or laparoscopy. INTERVENTION(S): Determination of polymorphisms of the ERalpha and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls. MAIN OUTCOME MEASURE(S): Frequency and distribution of PvuII and XbaI polymorphisms of ERalpha and of BslI, SspI, and RsaI polymorphisms of IL-10. RESULT(S): There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERalpha-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERalpha-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERalpha-XbaI was associated with endometriosis. CONCLUSION(S): The X allele of ERalpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18687423/Association_of_estrogen_receptor_alpha_and_interleukin_10_gene_polymorphisms_with_endometriosis_in_a_Chinese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)01015-7 DB - PRIME DP - Unbound Medicine ER -