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Relationships of neuroticism and extraversion with axis I and II comorbidity among patients with DSM-IV major depressive disorder.
J Affect Disord. 2009 Apr; 114(1-3):110-21.JA

Abstract

BACKGROUND

High comorbidity with axis I and II disorders among major depressive disorder (MDD) patients may in part be due to the predisposing personality dimensions of neuroticism and extraversion. However, a comprehensive view of this relationship is lacking.

METHODS

MDD patients (n=193) in the Vantaa Depression Study were interviewed at baseline and at 6 and 18 months with the SCAN and SCID-II, and a general population comparison group (n=388) surveyed by mail. Neuroticism and extraversion were measured with the Eysenck Personality Inventory. A dose-exposure relationship between standardized levels of neuroticism and extraversion and type and number of comorbid axis I and II disorders among patients with MDD was hypothesized.

RESULTS

Prevalence and number of comorbid axis I and II disorders increased significantly with increasing level of neuroticism. In contrast, as the level of extraversion increased, the prevalences of social phobia and cluster C personality disorders decreased. Patients with pure MDD or with any comorbid axis I or II disorder had z-scores of neuroticism of +0.46, +0.90 and +1.30 and of extraversion of -0.34, -0.47 and -0.84, respectively.

LIMITATIONS

Patients' personality scores were not pre-morbid.

CONCLUSION

Among MDD patients, a positive dose-exposure relationship appears to exist between neuroticism and prevalence and number of comorbid axis I and II disorders. A negative relationship exists between level of extraversion and prevalence of social phobia and cluster C personality disorders. These findings are consistent with the hypothesis that high neuroticism and low extraversion predispose to comorbid axis I and II disorders among patients with MDD.

Authors+Show Affiliations

Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18687471

Citation

Jylhä, Pekka, et al. "Relationships of Neuroticism and Extraversion With Axis I and II Comorbidity Among Patients With DSM-IV Major Depressive Disorder." Journal of Affective Disorders, vol. 114, no. 1-3, 2009, pp. 110-21.
Jylhä P, Melartin T, Isometsä E. Relationships of neuroticism and extraversion with axis I and II comorbidity among patients with DSM-IV major depressive disorder. J Affect Disord. 2009;114(1-3):110-21.
Jylhä, P., Melartin, T., & Isometsä, E. (2009). Relationships of neuroticism and extraversion with axis I and II comorbidity among patients with DSM-IV major depressive disorder. Journal of Affective Disorders, 114(1-3), 110-21. https://doi.org/10.1016/j.jad.2008.06.011
Jylhä P, Melartin T, Isometsä E. Relationships of Neuroticism and Extraversion With Axis I and II Comorbidity Among Patients With DSM-IV Major Depressive Disorder. J Affect Disord. 2009;114(1-3):110-21. PubMed PMID: 18687471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships of neuroticism and extraversion with axis I and II comorbidity among patients with DSM-IV major depressive disorder. AU - Jylhä,Pekka, AU - Melartin,Tarja, AU - Isometsä,Erkki, Y1 - 2008/08/06/ PY - 2008/03/27/received PY - 2008/06/17/revised PY - 2008/06/17/accepted PY - 2008/8/9/pubmed PY - 2009/7/23/medline PY - 2008/8/9/entrez SP - 110 EP - 21 JF - Journal of affective disorders JO - J Affect Disord VL - 114 IS - 1-3 N2 - BACKGROUND: High comorbidity with axis I and II disorders among major depressive disorder (MDD) patients may in part be due to the predisposing personality dimensions of neuroticism and extraversion. However, a comprehensive view of this relationship is lacking. METHODS: MDD patients (n=193) in the Vantaa Depression Study were interviewed at baseline and at 6 and 18 months with the SCAN and SCID-II, and a general population comparison group (n=388) surveyed by mail. Neuroticism and extraversion were measured with the Eysenck Personality Inventory. A dose-exposure relationship between standardized levels of neuroticism and extraversion and type and number of comorbid axis I and II disorders among patients with MDD was hypothesized. RESULTS: Prevalence and number of comorbid axis I and II disorders increased significantly with increasing level of neuroticism. In contrast, as the level of extraversion increased, the prevalences of social phobia and cluster C personality disorders decreased. Patients with pure MDD or with any comorbid axis I or II disorder had z-scores of neuroticism of +0.46, +0.90 and +1.30 and of extraversion of -0.34, -0.47 and -0.84, respectively. LIMITATIONS: Patients' personality scores were not pre-morbid. CONCLUSION: Among MDD patients, a positive dose-exposure relationship appears to exist between neuroticism and prevalence and number of comorbid axis I and II disorders. A negative relationship exists between level of extraversion and prevalence of social phobia and cluster C personality disorders. These findings are consistent with the hypothesis that high neuroticism and low extraversion predispose to comorbid axis I and II disorders among patients with MDD. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/18687471/Relationships_of_neuroticism_and_extraversion_with_axis_I_and_II_comorbidity_among_patients_with_DSM_IV_major_depressive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00264-4 DB - PRIME DP - Unbound Medicine ER -