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Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III.
Am J Clin Nutr. 2008 Aug; 88(2):272-81.AJ

Abstract

BACKGROUND

Dietary monounsaturated fat (MUFA) and complex carbohydrates have different effects on triglyceride-rich lipoprotein (TRL) metabolism.

OBJECTIVE

We hypothesized that apolipoprotein (apo) E and apo C-III might be involved in these dietary effects because of their crucial role in TRL metabolism.

DESIGN

Twelve adults consumed, for 3 wk each, 2 isocaloric diets: first a carbohydrate-rich diet (48% complex carbohydrate, 8% MUFAs) and then a MUFA-rich diet (31% complex carbohydrate, 24% MUFAs) 12 mo later. The dietary composition of other macronutrients in the 2 diets was similar. Body weight was kept constant. Postprandial apo B kinetic studies using stable-isotope tracers were performed after each dietary intervention. Multiple VLDL, intermediate-density lipoprotein (IDL), and LDL fractions were prepared on the basis of apo E and apo C-III contents.

RESULTS

The MUFA diet increased by approximately 4-6-fold, the secretion of VLDLs and IDLs containing both apo E and apo C-III (E+CIII+) (P < 0.05). These are TRLs that mostly cleared from the circulation and are minor precursors of LDL. The MUFA diet also decreased by 60% (P < 0.05) the secretion of the TRLs without apo E or apo C-III (major precursors of LDL in plasma) and decreased their flux to LDLs. Total LDL flux did not change because the MUFA diet increased the flux to LDL from E-CIII+ TRLs, a process that requires the removal of apo C-III. In addition, the MUFA diet significantly increased the TRL fractional catabolic rate by 50% and doubled the percentage of TRLs that were cleared rather than being converted to LDLs.

CONCLUSION

MUFA intake activates synthetic and rapid catabolic pathways for TRL metabolism that involve apo E and apo C-III and suppresses the metabolism of more slowly metabolized VLDLs and IDLs, which do not contain these apolipoproteins.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18689361

Citation

Zheng, Chunyu, et al. "Dietary Monounsaturated Fat Activates Metabolic Pathways for Triglyceride-rich Lipoproteins That Involve Apolipoproteins E and C-III." The American Journal of Clinical Nutrition, vol. 88, no. 2, 2008, pp. 272-81.
Zheng C, Khoo C, Furtado J, et al. Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. Am J Clin Nutr. 2008;88(2):272-81.
Zheng, C., Khoo, C., Furtado, J., Ikewaki, K., & Sacks, F. M. (2008). Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. The American Journal of Clinical Nutrition, 88(2), 272-81.
Zheng C, et al. Dietary Monounsaturated Fat Activates Metabolic Pathways for Triglyceride-rich Lipoproteins That Involve Apolipoproteins E and C-III. Am J Clin Nutr. 2008;88(2):272-81. PubMed PMID: 18689361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. AU - Zheng,Chunyu, AU - Khoo,Christina, AU - Furtado,Jeremy, AU - Ikewaki,Katsunori, AU - Sacks,Frank M, PY - 2008/8/12/pubmed PY - 2008/9/16/medline PY - 2008/8/12/entrez SP - 272 EP - 81 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 88 IS - 2 N2 - BACKGROUND: Dietary monounsaturated fat (MUFA) and complex carbohydrates have different effects on triglyceride-rich lipoprotein (TRL) metabolism. OBJECTIVE: We hypothesized that apolipoprotein (apo) E and apo C-III might be involved in these dietary effects because of their crucial role in TRL metabolism. DESIGN: Twelve adults consumed, for 3 wk each, 2 isocaloric diets: first a carbohydrate-rich diet (48% complex carbohydrate, 8% MUFAs) and then a MUFA-rich diet (31% complex carbohydrate, 24% MUFAs) 12 mo later. The dietary composition of other macronutrients in the 2 diets was similar. Body weight was kept constant. Postprandial apo B kinetic studies using stable-isotope tracers were performed after each dietary intervention. Multiple VLDL, intermediate-density lipoprotein (IDL), and LDL fractions were prepared on the basis of apo E and apo C-III contents. RESULTS: The MUFA diet increased by approximately 4-6-fold, the secretion of VLDLs and IDLs containing both apo E and apo C-III (E+CIII+) (P < 0.05). These are TRLs that mostly cleared from the circulation and are minor precursors of LDL. The MUFA diet also decreased by 60% (P < 0.05) the secretion of the TRLs without apo E or apo C-III (major precursors of LDL in plasma) and decreased their flux to LDLs. Total LDL flux did not change because the MUFA diet increased the flux to LDL from E-CIII+ TRLs, a process that requires the removal of apo C-III. In addition, the MUFA diet significantly increased the TRL fractional catabolic rate by 50% and doubled the percentage of TRLs that were cleared rather than being converted to LDLs. CONCLUSION: MUFA intake activates synthetic and rapid catabolic pathways for TRL metabolism that involve apo E and apo C-III and suppresses the metabolism of more slowly metabolized VLDLs and IDLs, which do not contain these apolipoproteins. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18689361/Dietary_monounsaturated_fat_activates_metabolic_pathways_for_triglyceride_rich_lipoproteins_that_involve_apolipoproteins_E_and_C_III_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/88.2.272 DB - PRIME DP - Unbound Medicine ER -