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Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.

Abstract

BACKGROUND

Fish intake, the major source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may reduce the risk of age-related macular degeneration (AMD).

OBJECTIVE

We investigated the association of oily fish and dietary DHA and EPA with neovascular AMD (NV-AMD).

DESIGN

Participants aged >/=65 y in the cross-sectional population-based EUREYE study underwent fundus photography and were interviewed by using a food-frequency questionnaire. Fundus images were graded by the International Classification System for Age Related Maculopathy. Questionnaire data were converted to nutrient intakes with the use of food-composition tables. Survey logistic regression was used to calculate odds ratios (ORs) and 95% CIs of energy-adjusted quartiles of EPA or DHA with NV-AMD, taking into account potential confounders.

RESULTS

Dietary intake data and fundus images were available for 105 cases with NV-AMD and for 2170 controls without any features of early or late AMD. Eating oily fish at least once per week compared with less than once per week was associated with a halving of the odds of NV-AMD (OR = 0.47; 95% CI: 0.33, 0.68; P = 0.002). Compared with the lowest quartile, there was a significant trend for decreased odds with increasing quartiles of either DHA or EPA. ORs in the highest quartiles were 0.32 (95% CI: 0.12, 0.87; P = 0.03) for DHA and 0.29 (95% CI: 0.11, 0.73; P = 0.02) for EPA.

CONCLUSIONS

Eating oily fish at least once per week compared with less than once per week was associated with a halving of the OR for NV-AMD.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

    , , , , , , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Confidence Intervals
    Cross-Sectional Studies
    Diet
    Diet Surveys
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Europe
    Feeding Behavior
    Female
    Fish Oils
    Humans
    Logistic Models
    Macular Degeneration
    Male
    Odds Ratio
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18689376

    Citation

    Augood, Cristina, et al. "Oily Fish Consumption, Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes, and Associations With Neovascular Age-related Macular Degeneration." The American Journal of Clinical Nutrition, vol. 88, no. 2, 2008, pp. 398-406.
    Augood C, Chakravarthy U, Young I, et al. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. Am J Clin Nutr. 2008;88(2):398-406.
    Augood, C., Chakravarthy, U., Young, I., Vioque, J., de Jong, P. T., Bentham, G., ... Fletcher, A. E. (2008). Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. The American Journal of Clinical Nutrition, 88(2), pp. 398-406.
    Augood C, et al. Oily Fish Consumption, Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes, and Associations With Neovascular Age-related Macular Degeneration. Am J Clin Nutr. 2008;88(2):398-406. PubMed PMID: 18689376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. AU - Augood,Cristina, AU - Chakravarthy,Usha, AU - Young,Ian, AU - Vioque,Jesus, AU - de Jong,Paulus T V M, AU - Bentham,Graham, AU - Rahu,Mati, AU - Seland,Johan, AU - Soubrane,Gisele, AU - Tomazzoli,Laura, AU - Topouzis,Fotis, AU - Vingerling,Johannes R, AU - Fletcher,Astrid E, PY - 2008/8/12/pubmed PY - 2008/9/16/medline PY - 2008/8/12/entrez SP - 398 EP - 406 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 88 IS - 2 N2 - BACKGROUND: Fish intake, the major source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may reduce the risk of age-related macular degeneration (AMD). OBJECTIVE: We investigated the association of oily fish and dietary DHA and EPA with neovascular AMD (NV-AMD). DESIGN: Participants aged >/=65 y in the cross-sectional population-based EUREYE study underwent fundus photography and were interviewed by using a food-frequency questionnaire. Fundus images were graded by the International Classification System for Age Related Maculopathy. Questionnaire data were converted to nutrient intakes with the use of food-composition tables. Survey logistic regression was used to calculate odds ratios (ORs) and 95% CIs of energy-adjusted quartiles of EPA or DHA with NV-AMD, taking into account potential confounders. RESULTS: Dietary intake data and fundus images were available for 105 cases with NV-AMD and for 2170 controls without any features of early or late AMD. Eating oily fish at least once per week compared with less than once per week was associated with a halving of the odds of NV-AMD (OR = 0.47; 95% CI: 0.33, 0.68; P = 0.002). Compared with the lowest quartile, there was a significant trend for decreased odds with increasing quartiles of either DHA or EPA. ORs in the highest quartiles were 0.32 (95% CI: 0.12, 0.87; P = 0.03) for DHA and 0.29 (95% CI: 0.11, 0.73; P = 0.02) for EPA. CONCLUSIONS: Eating oily fish at least once per week compared with less than once per week was associated with a halving of the OR for NV-AMD. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18689376/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/88.2.398 DB - PRIME DP - Unbound Medicine ER -