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Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child.

Abstract

BACKGROUND

Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes.

OBJECTIVE

We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced beta cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >/=1 other antibody, overt type 1 diabetes, or both.

DESIGN

The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements.

RESULTS

Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced beta cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1.

CONCLUSION

High maternal intake of retinol, beta-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced beta cell autoimmunity in early childhood.

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  • Authors+Show Affiliations

    ,

    Tampere School of Public Health, University of Tampere, Tampere, Finland.

    , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Autoantibodies
    Child
    Child, Preschool
    Cohort Studies
    Diabetes Mellitus, Type 1
    Female
    Finland
    Genetic Predisposition to Disease
    HLA-DQ Antigens
    HLA-DQ beta-Chains
    Humans
    Infant
    Islets of Langerhans
    Maternal Nutritional Physiological Phenomena
    Pregnancy
    Prenatal Exposure Delayed Effects
    Prenatal Nutritional Physiological Phenomena
    Prospective Studies
    Risk Assessment
    Risk Factors
    Trace Elements
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18689383

    Citation

    Uusitalo, Liisa, et al. "Intake of Antioxidant Vitamins and Trace Elements During Pregnancy and Risk of Advanced Beta Cell Autoimmunity in the Child." The American Journal of Clinical Nutrition, vol. 88, no. 2, 2008, pp. 458-64.
    Uusitalo L, Kenward MG, Virtanen SM, et al. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child. Am J Clin Nutr. 2008;88(2):458-64.
    Uusitalo, L., Kenward, M. G., Virtanen, S. M., Uusitalo, U., Nevalainen, J., Niinistö, S., ... Knip, M. (2008). Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child. The American Journal of Clinical Nutrition, 88(2), pp. 458-64.
    Uusitalo L, et al. Intake of Antioxidant Vitamins and Trace Elements During Pregnancy and Risk of Advanced Beta Cell Autoimmunity in the Child. Am J Clin Nutr. 2008;88(2):458-64. PubMed PMID: 18689383.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child. AU - Uusitalo,Liisa, AU - Kenward,Mike G, AU - Virtanen,Suvi M, AU - Uusitalo,Ulla, AU - Nevalainen,Jaakko, AU - Niinistö,Sari, AU - Kronberg-Kippilä,Carina, AU - Ovaskainen,Marja-Leena, AU - Marjamäki,Liisa, AU - Simell,Olli, AU - Ilonen,Jorma, AU - Veijola,Riitta, AU - Knip,Mikael, PY - 2008/8/12/pubmed PY - 2008/9/16/medline PY - 2008/8/12/entrez SP - 458 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 88 IS - 2 N2 - BACKGROUND: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced beta cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >/=1 other antibody, overt type 1 diabetes, or both. DESIGN: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. RESULTS: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced beta cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. CONCLUSION: High maternal intake of retinol, beta-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced beta cell autoimmunity in early childhood. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18689383/Intake_of_antioxidant_vitamins_and_trace_elements_during_pregnancy_and_risk_of_advanced_beta_cell_autoimmunity_in_the_child_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/88.2.458 DB - PRIME DP - Unbound Medicine ER -