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Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras.
Am J Trop Med Hyg. 2008 Aug; 79(2):262-6.AJ

Abstract

The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary; from them, 73 were DHF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children.

Authors+Show Affiliations

Department of Microbiology, National Autonomous University of Honduras, Tegucigalpa, Honduras.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18689634

Citation

De Rivera, Ivette Lorenzana, et al. "Humoral Immune Response of Dengue Hemorrhagic Fever Cases in Children From Tegucigalpa, Honduras." The American Journal of Tropical Medicine and Hygiene, vol. 79, no. 2, 2008, pp. 262-6.
De Rivera IL, Parham L, Murillo W, et al. Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras. Am J Trop Med Hyg. 2008;79(2):262-6.
De Rivera, I. L., Parham, L., Murillo, W., Moncada, W., & Vazquez, S. (2008). Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras. The American Journal of Tropical Medicine and Hygiene, 79(2), 262-6.
De Rivera IL, et al. Humoral Immune Response of Dengue Hemorrhagic Fever Cases in Children From Tegucigalpa, Honduras. Am J Trop Med Hyg. 2008;79(2):262-6. PubMed PMID: 18689634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras. AU - De Rivera,Ivette Lorenzana, AU - Parham,Leda, AU - Murillo,Wendy, AU - Moncada,Walter, AU - Vazquez,Susana, PY - 2008/8/12/pubmed PY - 2008/9/5/medline PY - 2008/8/12/entrez SP - 262 EP - 6 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 79 IS - 2 N2 - The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary; from them, 73 were DHF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/18689634/Humoral_immune_response_of_dengue_hemorrhagic_fever_cases_in_children_from_Tegucigalpa_Honduras_ L2 - http://www.diseaseinfosearch.org/result/2187 DB - PRIME DP - Unbound Medicine ER -