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A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents.
Saudi Med J. 2008 Aug; 29(8):1130-4.SM

Abstract

OBJECTIVE

To evaluate the effect of metformin treatment on the risperidone-induced body weight gain in patients.

METHODS

In a 12-weeks, double-blind, placebo controlled, randomized trial between October 2006 and October 2007 which was conducted in the Child and Adolescent Psychiatric Consultation Center of Isfahan University of Medical Sciences, 49 patients were entered the study with schizophrenia diagnosis. Then metformin (500 mg bid) or placebo was administrated with risperidone (6 mg) for the patients. Weight, height, and body mass index BMI were measured at the beginning, at 4 weeks, and at 12 weeks of the study. Changes in weight and BMI were evaluated by using repeated measures analysis of variance.

RESULTS

Seventeen patients were excluded from the study. Repeated measure analysis of variances showed a significant difference between weight and BMI in both metformin (p<0.001, p<0.015) and placebo group (p<0.013, p<0.005).

CONCLUSION

Metformin treatment did not show a significant effect to control the body weight of patients after 12 weeks.

Authors+Show Affiliations

Department of Psychiatry, Isfahan University of Medical Sciences, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18690305

Citation

Arman, Soroor, et al. "A Randomized, Double-blind, Placebo-controlled Trial of Metformin Treatment for Weight Gain Associated With Initiation of Risperidone in Children and Adolescents." Saudi Medical Journal, vol. 29, no. 8, 2008, pp. 1130-4.
Arman S, Sadramely MR, Nadi M, et al. A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. Saudi Med J. 2008;29(8):1130-4.
Arman, S., Sadramely, M. R., Nadi, M., & Koleini, N. (2008). A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. Saudi Medical Journal, 29(8), 1130-4.
Arman S, et al. A Randomized, Double-blind, Placebo-controlled Trial of Metformin Treatment for Weight Gain Associated With Initiation of Risperidone in Children and Adolescents. Saudi Med J. 2008;29(8):1130-4. PubMed PMID: 18690305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. AU - Arman,Soroor, AU - Sadramely,Mohammad R, AU - Nadi,Mortaza, AU - Koleini,Navid, PY - 2008/8/12/pubmed PY - 2008/11/19/medline PY - 2008/8/12/entrez SP - 1130 EP - 4 JF - Saudi medical journal JO - Saudi Med J VL - 29 IS - 8 N2 - OBJECTIVE: To evaluate the effect of metformin treatment on the risperidone-induced body weight gain in patients. METHODS: In a 12-weeks, double-blind, placebo controlled, randomized trial between October 2006 and October 2007 which was conducted in the Child and Adolescent Psychiatric Consultation Center of Isfahan University of Medical Sciences, 49 patients were entered the study with schizophrenia diagnosis. Then metformin (500 mg bid) or placebo was administrated with risperidone (6 mg) for the patients. Weight, height, and body mass index BMI were measured at the beginning, at 4 weeks, and at 12 weeks of the study. Changes in weight and BMI were evaluated by using repeated measures analysis of variance. RESULTS: Seventeen patients were excluded from the study. Repeated measure analysis of variances showed a significant difference between weight and BMI in both metformin (p<0.001, p<0.015) and placebo group (p<0.013, p<0.005). CONCLUSION: Metformin treatment did not show a significant effect to control the body weight of patients after 12 weeks. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/18690305/A_randomized_double_blind_placebo_controlled_trial_of_metformin_treatment_for_weight_gain_associated_with_initiation_of_risperidone_in_children_and_adolescents_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -