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Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats.
Phytother Res. 2008 Nov; 22(11):1506-10.PR

Abstract

The present study aimed to investigate the protective effect of Spirulina platensis (SP) on gentamicin sulphate (GS)-induced changes in the levels of lipid peroxidation and endogenous antioxidants in the kidney of rats. Sprague-Dawley rats were treated in separate groups as follows for 7 consecutive days: control (C), gentamicin sulphate (100 mg/kg i.p.) (GS), Spirulina platensis (1000 mg/kg orally) (SP) and Spirulina platensis (1000 mg/kg orally) plus gentamicin sulphate (100 mg/kg i.p.) (SP + GS). The degree of protection was evaluated by determining the effects of Spirulina platensis on malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPX) and nitric oxide (NO), and plasma creatinine and urea levels were estimated in kidney homogenates to evaluate antioxidant activity, and the kidney was histologically examined as well. Spirulina platensis elicited significant nephroprotective activity by decreasing lipid peroxidation (MDA) and elevated the levels of GSH, SOD, GPX, NO, creatinine and urea. Furthermore, these biochemical observations were supplemented by histological examination of the rat kidneys. In conclusion, the present study indicates a very important role of reactive oxygen species (ROS) and the relation to renal dysfunction and point to the therapeutic potential of Spirulina platensis in gentamicin sulphate induced nephrotoxicity.

Authors+Show Affiliations

Department of Physiology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey. karadenizali@atauni.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18690652

Citation

Karadeniz, Ali, et al. "Spirulina Platensis Protects Against Gentamicin-induced Nephrotoxicity in Rats." Phytotherapy Research : PTR, vol. 22, no. 11, 2008, pp. 1506-10.
Karadeniz A, Yildirim A, Simsek N, et al. Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats. Phytother Res. 2008;22(11):1506-10.
Karadeniz, A., Yildirim, A., Simsek, N., Kalkan, Y., & Celebi, F. (2008). Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats. Phytotherapy Research : PTR, 22(11), 1506-10. https://doi.org/10.1002/ptr.2522
Karadeniz A, et al. Spirulina Platensis Protects Against Gentamicin-induced Nephrotoxicity in Rats. Phytother Res. 2008;22(11):1506-10. PubMed PMID: 18690652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats. AU - Karadeniz,Ali, AU - Yildirim,Abdulkadir, AU - Simsek,Nejdet, AU - Kalkan,Yildiray, AU - Celebi,Fikret, PY - 2008/8/12/pubmed PY - 2008/12/17/medline PY - 2008/8/12/entrez SP - 1506 EP - 10 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 11 N2 - The present study aimed to investigate the protective effect of Spirulina platensis (SP) on gentamicin sulphate (GS)-induced changes in the levels of lipid peroxidation and endogenous antioxidants in the kidney of rats. Sprague-Dawley rats were treated in separate groups as follows for 7 consecutive days: control (C), gentamicin sulphate (100 mg/kg i.p.) (GS), Spirulina platensis (1000 mg/kg orally) (SP) and Spirulina platensis (1000 mg/kg orally) plus gentamicin sulphate (100 mg/kg i.p.) (SP + GS). The degree of protection was evaluated by determining the effects of Spirulina platensis on malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPX) and nitric oxide (NO), and plasma creatinine and urea levels were estimated in kidney homogenates to evaluate antioxidant activity, and the kidney was histologically examined as well. Spirulina platensis elicited significant nephroprotective activity by decreasing lipid peroxidation (MDA) and elevated the levels of GSH, SOD, GPX, NO, creatinine and urea. Furthermore, these biochemical observations were supplemented by histological examination of the rat kidneys. In conclusion, the present study indicates a very important role of reactive oxygen species (ROS) and the relation to renal dysfunction and point to the therapeutic potential of Spirulina platensis in gentamicin sulphate induced nephrotoxicity. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18690652/Spirulina_platensis_protects_against_gentamicin_induced_nephrotoxicity_in_rats_ L2 - https://doi.org/10.1002/ptr.2522 DB - PRIME DP - Unbound Medicine ER -