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Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity.
J Neurochem. 2008 Oct; 107(1):230-40.JN

Abstract

There is great interest in soy isoflavones as alternatives to endogenous estrogens not only in hormonal pathologies, but also in inflammatory, neurodegenerative diseases, and pain. We investigated the effect of the isoflavone genistein on neuropathic pain. Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells. Neuropathy was induced in mice by means of chronic sciatic nerve constriction, and the subcutaneous administration of genistein from the third day after the lesion reversed pain hypersensitivity in a time- and dose-dependent manner. This effect may have been due to the activation of classical nuclear receptor and/or anti-oxidant, anti-inflammatory, and immunomodulating properties of genistein. The fact that a specific ERbeta antagonist prevented both its anti-allodynic and anti-hyperalgesic action, whereas a specific ERalpha antagonist was ineffective and a non-selective ER antagonist only reversed the anti-allodynic effect, suggests the involvement of ERbeta. Antioxidant effects are also involved as the anti-nociceptive dose reversed the increase in reactive oxygen species and malondialdehyde in injured paw tissues, and increased the activity of anti-oxidant enzymes. The phytoestrogen had immunomodulatory and anti-inflammatory activities as it reduced peripheral and central nuclear factor-kappaB, nitric oxide system and pro-inflammatory cytokine over-activation. Taken together, our results suggest that genistein could ameliorate painful neuropathy by multiple mechanisms.

Authors+Show Affiliations

Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18691380

Citation

Valsecchi, Anna Elisa, et al. "Genistein, a Natural Phytoestrogen From Soy, Relieves Neuropathic Pain Following Chronic Constriction Sciatic Nerve Injury in Mice: Anti-inflammatory and Antioxidant Activity." Journal of Neurochemistry, vol. 107, no. 1, 2008, pp. 230-40.
Valsecchi AE, Franchi S, Panerai AE, et al. Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity. J Neurochem. 2008;107(1):230-40.
Valsecchi, A. E., Franchi, S., Panerai, A. E., Sacerdote, P., Trovato, A. E., & Colleoni, M. (2008). Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity. Journal of Neurochemistry, 107(1), 230-40. https://doi.org/10.1111/j.1471-4159.2008.05614.x
Valsecchi AE, et al. Genistein, a Natural Phytoestrogen From Soy, Relieves Neuropathic Pain Following Chronic Constriction Sciatic Nerve Injury in Mice: Anti-inflammatory and Antioxidant Activity. J Neurochem. 2008;107(1):230-40. PubMed PMID: 18691380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity. AU - Valsecchi,Anna Elisa, AU - Franchi,Silvia, AU - Panerai,Alberto Emilio, AU - Sacerdote,Paola, AU - Trovato,Anna Elisa, AU - Colleoni,Mariapia, Y1 - 2008/08/08/ PY - 2008/8/12/pubmed PY - 2008/11/4/medline PY - 2008/8/12/entrez SP - 230 EP - 40 JF - Journal of neurochemistry JO - J Neurochem VL - 107 IS - 1 N2 - There is great interest in soy isoflavones as alternatives to endogenous estrogens not only in hormonal pathologies, but also in inflammatory, neurodegenerative diseases, and pain. We investigated the effect of the isoflavone genistein on neuropathic pain. Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells. Neuropathy was induced in mice by means of chronic sciatic nerve constriction, and the subcutaneous administration of genistein from the third day after the lesion reversed pain hypersensitivity in a time- and dose-dependent manner. This effect may have been due to the activation of classical nuclear receptor and/or anti-oxidant, anti-inflammatory, and immunomodulating properties of genistein. The fact that a specific ERbeta antagonist prevented both its anti-allodynic and anti-hyperalgesic action, whereas a specific ERalpha antagonist was ineffective and a non-selective ER antagonist only reversed the anti-allodynic effect, suggests the involvement of ERbeta. Antioxidant effects are also involved as the anti-nociceptive dose reversed the increase in reactive oxygen species and malondialdehyde in injured paw tissues, and increased the activity of anti-oxidant enzymes. The phytoestrogen had immunomodulatory and anti-inflammatory activities as it reduced peripheral and central nuclear factor-kappaB, nitric oxide system and pro-inflammatory cytokine over-activation. Taken together, our results suggest that genistein could ameliorate painful neuropathy by multiple mechanisms. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/18691380/Genistein_a_natural_phytoestrogen_from_soy_relieves_neuropathic_pain_following_chronic_constriction_sciatic_nerve_injury_in_mice:_anti_inflammatory_and_antioxidant_activity_ L2 - https://doi.org/10.1111/j.1471-4159.2008.05614.x DB - PRIME DP - Unbound Medicine ER -