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Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats.
Food Chem Toxicol. 2008 Sep; 46(9):3182-5.FC

Abstract

Oxidative damage is involved in the pathogenesis of various hepatic injuries. In the present study the capacity of Commiphora berryi (Arn) Engl bark as an antioxidant to protect against CCl(4)-induced oxidative stress and hepatotoxicity in Albino Wistar rats was investigated. Intraperitoneal injection of CCl(4), administered twice a week, produced a marked elevation in the serum levels of aspartate transaminase, alanine transaminase, alkaline phosphatase and bilirubin. Histopathological analysis of the liver of CCl(4)-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD, GPx and CAT. Daily oral administration of methanolic extract of C. berryi (Arn) Engl bark at 100 and 200mg/kg doses for 15 days produced a dose-dependent reduction in the serum levels of liver enzymes. Treatment with C. berryi normalized various biochemical parameters of oxidative stress and was compared with standard Silymarin. Therefore, the results of this study show that C. berryi (Arn) Engl bark can be proposed to protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Gowri Shankar NL
Department of Pharmacognosy, Swamy Vivekananda Institute of Pharmaceutical Sciences, Andhra Pradesh, India. nlgowri@yahoo.co.in
Manavalan R
No affiliation info available
Venkappayya D
No affiliation info available
David Raj C
No affiliation info available

MeSH

Alanine TransaminaseAnimalsAntioxidantsAspartate AminotransferasesCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryCommiphoraLiverOxidative StressPlant BarkPlant ExtractsProtective AgentsRatsSilymarin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18691629

Citation

Gowri Shankar, N L., et al. "Hepatoprotective and Antioxidant Effects of Commiphora Berryi (Arn) Engl Bark Extract Against CCl(4)-induced Oxidative Damage in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 9, 2008, pp. 3182-5.
Gowri Shankar NL, Manavalan R, Venkappayya D, et al. Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. Food Chem Toxicol. 2008;46(9):3182-5.
Gowri Shankar, N. L., Manavalan, R., Venkappayya, D., & David Raj, C. (2008). Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(9), 3182-5. https://doi.org/10.1016/j.fct.2008.07.010
Gowri Shankar NL, et al. Hepatoprotective and Antioxidant Effects of Commiphora Berryi (Arn) Engl Bark Extract Against CCl(4)-induced Oxidative Damage in Rats. Food Chem Toxicol. 2008;46(9):3182-5. PubMed PMID: 18691629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. AU - Gowri Shankar,N L, AU - Manavalan,R, AU - Venkappayya,D, AU - David Raj,C, Y1 - 2008/07/22/ PY - 2007/12/06/received PY - 2008/02/21/revised PY - 2008/07/11/accepted PY - 2008/8/12/pubmed PY - 2008/11/7/medline PY - 2008/8/12/entrez SP - 3182 EP - 5 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 9 N2 - Oxidative damage is involved in the pathogenesis of various hepatic injuries. In the present study the capacity of Commiphora berryi (Arn) Engl bark as an antioxidant to protect against CCl(4)-induced oxidative stress and hepatotoxicity in Albino Wistar rats was investigated. Intraperitoneal injection of CCl(4), administered twice a week, produced a marked elevation in the serum levels of aspartate transaminase, alanine transaminase, alkaline phosphatase and bilirubin. Histopathological analysis of the liver of CCl(4)-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD, GPx and CAT. Daily oral administration of methanolic extract of C. berryi (Arn) Engl bark at 100 and 200mg/kg doses for 15 days produced a dose-dependent reduction in the serum levels of liver enzymes. Treatment with C. berryi normalized various biochemical parameters of oxidative stress and was compared with standard Silymarin. Therefore, the results of this study show that C. berryi (Arn) Engl bark can be proposed to protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18691629/Hepatoprotective_and_antioxidant_effects_of_Commiphora_berryi__Arn__Engl_bark_extract_against_CCl_4__induced_oxidative_damage_in_rats_ DB - PRIME DP - Unbound Medicine ER -