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Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice.
Food Chem Toxicol. 2008 Sep; 46(9):3193-9.FC

Abstract

Morchella esculenta (L) Pers. is an excellently edible and delicious morel mushroom found growing in the temperate forests. The mycelium of this mushroom is widely used as a flavouring agent. The current investigation was undertaken to explore the protective effect of the aqueous-ethanol extract of cultured mycelium of M. esculenta against cisplatin and gentamicin induced acute renal toxicity in Swiss albino mice. Cisplatin and gentamicin when administered induced a marked renal failure, characterized by a significant increase in serum urea and creatinine concentrations. Treatment with the extract at 250 and 500mg/kg body weight decreased the cisplatin and gentamicin induced increase in serum creatinine and urea levels. Treatment with the extract also restored the depleted antioxidant defense system. The decreased activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) in the kidneys consequent to cisplatin and gentamicin administration was significantly elevated. The enhanced renal antioxidant defense system also prevented the tissue lipid peroxidation. The experimental results suggest that aqueous-ethanol extract of morel mushroom, M. esculenta mycelium protected cisplatin and gentamicin induced nephrotoxicity possibly by enhancing renal antioxidant system. The findings thus suggest the potential therapeutic use of morel mushroom mycelium as a novel nephroprotective agent.

Authors+Show Affiliations

Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18692113

Citation

Nitha, B, and K K. Janardhanan. "Aqueous-ethanolic Extract of Morel Mushroom Mycelium Morchella Esculenta, Protects Cisplatin and Gentamicin Induced Nephrotoxicity in Mice." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 9, 2008, pp. 3193-9.
Nitha B, Janardhanan KK. Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food Chem Toxicol. 2008;46(9):3193-9.
Nitha, B., & Janardhanan, K. K. (2008). Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(9), 3193-9. https://doi.org/10.1016/j.fct.2008.07.007
Nitha B, Janardhanan KK. Aqueous-ethanolic Extract of Morel Mushroom Mycelium Morchella Esculenta, Protects Cisplatin and Gentamicin Induced Nephrotoxicity in Mice. Food Chem Toxicol. 2008;46(9):3193-9. PubMed PMID: 18692113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. AU - Nitha,B, AU - Janardhanan,K K, Y1 - 2008/07/22/ PY - 2007/12/30/received PY - 2008/06/28/revised PY - 2008/07/14/accepted PY - 2008/8/12/pubmed PY - 2008/11/7/medline PY - 2008/8/12/entrez SP - 3193 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 9 N2 - Morchella esculenta (L) Pers. is an excellently edible and delicious morel mushroom found growing in the temperate forests. The mycelium of this mushroom is widely used as a flavouring agent. The current investigation was undertaken to explore the protective effect of the aqueous-ethanol extract of cultured mycelium of M. esculenta against cisplatin and gentamicin induced acute renal toxicity in Swiss albino mice. Cisplatin and gentamicin when administered induced a marked renal failure, characterized by a significant increase in serum urea and creatinine concentrations. Treatment with the extract at 250 and 500mg/kg body weight decreased the cisplatin and gentamicin induced increase in serum creatinine and urea levels. Treatment with the extract also restored the depleted antioxidant defense system. The decreased activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) in the kidneys consequent to cisplatin and gentamicin administration was significantly elevated. The enhanced renal antioxidant defense system also prevented the tissue lipid peroxidation. The experimental results suggest that aqueous-ethanol extract of morel mushroom, M. esculenta mycelium protected cisplatin and gentamicin induced nephrotoxicity possibly by enhancing renal antioxidant system. The findings thus suggest the potential therapeutic use of morel mushroom mycelium as a novel nephroprotective agent. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18692113/Aqueous_ethanolic_extract_of_morel_mushroom_mycelium_Morchella_esculenta_protects_cisplatin_and_gentamicin_induced_nephrotoxicity_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00400-6 DB - PRIME DP - Unbound Medicine ER -